Scientific article
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English

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Published inChromosome research, vol. 21, no. 2, p. 101-106
Publication date2013
Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.

Keywords
  • Autoantigens/genetics/metabolism
  • Centromere
  • Chromosomal Proteins, Non-Histone/genetics/metabolism
  • Histones/genetics/metabolism
  • Humans
  • Kinetochores
  • Scleroderma, Systemic/genetics
  • Terminology as Topic
Citation (ISO format)
EARNSHAW, W C, MERALDI, Patrick. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. In: Chromosome research, 2013, vol. 21, n° 2, p. 101–106. doi: 10.1007/s10577-013-9347-y
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Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0967-3849
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