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Title

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Authors
Earnshaw, W C
Allshire, R C
Black, B E
Bloom, K
Brinkley, B R
Brown, W
Cheeseman, I M
Choo, K H A
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Published in Chromosome Research. 2013, vol. 21, no. 2, p. 101-6
Abstract The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
Keywords Autoantigens/genetics/metabolismCentromereChromosomal Proteins, Non-Histone/genetics/metabolismHistones/genetics/metabolismHumansKinetochoresScleroderma, Systemic/geneticsTerminology as Topic
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PMID: 23580138
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Article (Published version) (104 Kb) - public document Free access
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Research group Groupe Meraldi Patrick (physiologie cellulaire et métabolisme) (922)
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EARNSHAW, W C et al. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. In: Chromosome Research, 2013, vol. 21, n° 2, p. 101-6. https://archive-ouverte.unige.ch/unige:33724

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Deposited on : 2014-01-27

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