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Title

Enantioselective 1,4-additions of ClMeAl(CH=CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones

Authors
Willcox, Darren
Woodward, Simon
Published in Chemical Communications. 2014, vol. 50, no. 14, p. 1655-1657
Abstract Chloromethylvinyl alanes (E)-ClMeAl(CH[double bond, length as m-dash]CHR) prepared directly from terminal alkynes undergo 1,4-addition to cyclohexenone and 3-methylcyclohexenone in moderate to good yield (30–70%) and good to excellent stereoselectivity (80–98% ee) using readily available copper(I) sources and chiral ligands.
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Other version: http://xlink.rsc.org/?DOI=c3cc48191c
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WILLCOX, Darren, WOODWARD, Simon, ALEXAKIS, Alexandre. Enantioselective 1,4-additions of ClMeAl(CH=CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones. In: Chemical Communications, 2014, vol. 50, n° 14, p. 1655-1657. https://archive-ouverte.unige.ch/unige:33671

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Deposited on : 2014-01-24

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