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Diabète et ostéoporose

Published in Revue médicale suisse. 2013, vol. 9, no. 390, p. 1256-1259
Abstract Diabetes alters bone mass and/or quality and increases fracture risk. However, in type 2 diabetes, bone mineral density (BMD) is usually not diminished, pertaining to increased weight and fat mass, which complicates the diagnosis of osteoporosis by DXA (T-score <-2.5). Similarly, estimates of fracture probability by FRAX may underestimate fracture risk in type 2 diabetes. Adequate glycemic control with insulin and/or oral antidiabetics decreases fracture risk, whereas thiazolidinediones increase it. Eventually, osteoporosis drugs such as bisphosphonates and SERMs seem to have similar efficacy in diabetic and non-diabetic patients.
Keywords Absorptiometry, PhotonBone DensityBone Density Conservation Agents/therapeutic useDiabetes Mellitus, Type 2/complications/drug therapyHumansHypoglycemic Agents/adverse effects/therapeutic useOsteoporosis/diagnosis/drug therapy/etiologyOsteoporotic Fractures/etiology/prevention & controlSelective Estrogen Receptor Modulators/therapeutic use
PMID: 23821843
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Other version: http://rms.medhyg.ch/numero-390-page-1256.htm
Research group Génétique des Ostéoporoses (544)
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FERRARI, Serge Livio. Diabète et ostéoporose. In: Revue médicale suisse, 2013, vol. 9, n° 390, p. 1256-1259. https://archive-ouverte.unige.ch/unige:33642

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Deposited on : 2014-01-24

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