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Activation in the Face Perception Network In Autism Spectrum Disorder and 22q11.2 Deletion Syndrome Before and After Vis-À-Vis: A Remediation Program to Improve Socio-Emotional Functioning

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Denomination Maîtrise universitaire interdisciplinaire en neurosciences
Defense Maîtrise : Univ. Genève, 2013
Abstract Socio- emotional impairments are key components of both autism spectrum disorders (ASD) and 22q11.2 deletion syndrome (22q11DS), a genetic condition that is caused by a deletion on chromosome 22 (Gothelf et al., 2001; Swillen et al., 2001; Humphreys et al., 2008). Among these socio-emotional deficits, face recognition is considered to be a core problem in ASD (Klin et al., 2002; Schultz et al., 2003; Hubl et al., 2003; Bradshaw et al., 2011;Wiegelt et al., 2012) and one that is also observed in 22q11DS (Glaser et al., 2007; Andersson et al., 2008; Campbell et al., 2010; Glaser et al., 2010). Studies show that this face recognition problem is related to the lack of attention to the eyes since patients of both disorders spend less time looking at the eyes and show more difficulty discriminating them, compared to the mouth area (Wiegelt, et al.2012; Tanaka et al., 2012; Rutherford et al, 2007; Riby et al., 2009; Klin et al., 2002; Glaser et al., 2010; Mccabe et al., 2010). Many fMRI studies show reduced activity in the fusiform face area (FFA) for faces in ASD which has been linked to this abnormal scan-path while viewing faces (Humphreys et al., 2008; Pelphrey et al., 2007;Hubl et al., 2003; Schultz et al. 2000; Morris et al., 2007, Klin et al., 2002). In 22q11DS, reduced functional activation, as well as structural differences, in the fusiform gyrus (FG) and medial temporal areas have also been observed (Schaer et al., 2010; Glaser et al., 2007;Andersson et al., 2007; Campbell et al., 2006; Kates et al., 2006; Van Ameelsvort et al., 2006)...
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KARAGOZ UZEL, Ayca. Activation in the Face Perception Network In Autism Spectrum Disorder and 22q11.2 Deletion Syndrome Before and After Vis-À-Vis: A Remediation Program to Improve Socio-Emotional Functioning. Université de Genève. Maîtrise, 2013. https://archive-ouverte.unige.ch/unige:33630

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Deposited on : 2014-01-24

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