The authors describe the results of a program for the management of Buruli ulcers in Akonolinga (Cameroon). Its principal objective is to improve the diagnosis of dermatologic lesions and thereby to improve the indications for specific antibiotic therapy. This study, conducted in February, 2013, included 271 patients. Differential diagnosis of suspicious lesions was best with diagnostic examinations completed by histologic examination of a punch biopsy sample and advice from expert dermatologists.