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Regions of interest-based discriminant analysis of DaTSCAN SPECT and FDG-PET for the classification of dementia

ContributorsGaribotto, Valentinaorcid; Montandon, Marie Louise; Viaud, Claire Tabouret; Allaoua, Mohamed; Assal, Frédéric; Burkhard, Pierreorcid; Ratib, Osman; Zaidi, Habiborcid
Published inClinical nuclear medicine, vol. 38, no. 3, p. e112-117
Publication date2013
Abstract

Neuroimaging is increasingly used to support the clinical diagnosis of patients with cognitive impairment. Dopamine transporter (DAT) imaging, such as DaTSCAN SPECT, tests the integrity of the nigrostriatal pathway, whereas FDG-PET identifies typical patterns of cortical and subcortical hypometabolism. The aim of this study was to assess the relative contribution of DAT and regional glucose metabolism imaging to the differential diagnosis.

Keywords
  • Aged
  • Aged, 80 and over
  • Biological Transport
  • Dementia/metabolism/radionuclide imaging
  • Discriminant Analysis
  • Dopamine Plasma Membrane Transport Proteins/metabolism
  • Female
  • Fluorodeoxyglucose F18/diagnostic use/metabolism
  • Follow-Up Studies
  • Humans
  • Image Processing, Computer-Assisted/methods
  • Male
  • Middle Aged
  • Positron-Emission Tomography/methods
  • Retrospective Studies
  • Tomography, Emission-Computed, Single-Photon/methods
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Research groups
Citation (ISO format)
GARIBOTTO, Valentina et al. Regions of interest-based discriminant analysis of DaTSCAN SPECT and FDG-PET for the classification of dementia. In: Clinical nuclear medicine, 2013, vol. 38, n° 3, p. e112–117. doi: 10.1097/RLU.0b013e318279b991
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accessLevelRestricted
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ISSN of the journal0363-9762
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