UNIGE document Scientific Article
previous document  unige:33606  next document
add to browser collection
Title

Levodopa does not change cerebral vasoreactivity in Parkinson's disease

Authors
Krainik, Alexandre
Maillet, Audrey
Troprès, Irène
Lamalle, Laurent
Thobois, Stephane
Fraix, Valerie
show hidden authors show all authors [1 - 13]
Published in Movement Disorders. 2013, vol. 28, no. 4, p. 469-75
Abstract The aim of this work was to study cerebral vasoreactivity to hypercapnia in Parkinson's disease (PD) before and after levodopa administration. The prospective study was conducted in 20 patients presenting with PD, using 3T blood oxygenation level-dependent (BOLD) functional MRI (fMRI) covering the whole brain. The hypercapnic stimulus was block-designed using carbogen inhalation, a gas mixture of 7% CO2 and 93% O2, before (OFF) and 60 minutes after administration of a suprathreshold (120%) therapeutic L-dopa dose (ON). Ten age-matched controls were enrolled for between-group comparisons. Analyses were conducted with a random effects model and corrected for multiple comparisons. No adverse reaction to the hypercapnic stimulus was reported. However, 10 patients and 2 controls were excluded because of incomplete protocol realization, inappropriate hypercapnic stimulus, or excessive movements, leaving 10 patients and 8 controls for further analyses. The hypercapnic stimulus increased whole-brain BOLD signal of 1.48% ± 0.06% (mean ± standard error) in controls, 1.59% ± 0.05% in patients OFF, and 1.62% ± 0.09% in patients ON. Regions of interest analyses showed a signal increase in gray matter of 2.60% ± 0.16% in controls, 2.89% ± 0.21% in patients OFF, and 2.87% ± 0.12% in patients ON. No global or regional significant difference was detected, when comparing patients OFF and ON L-dopa, or between patients and controls. Contrary to Alzheimer's disease, the vasoreactivity to hypercapnia was normal in PD before and after L-dopa administration, compared to controls. This negative result is an important finding, especially for neuroscientists using fMRI to investigate motricity and cognition, discarding a significant confounding effect.
Keywords AdultAgedAntiparkinson Agents/therapeutic useFemaleHumansImage Processing, Computer-AssistedLevodopa/therapeutic useMagnetic Resonance Imaging/methodsMaleMiddle AgedNeuropsychological TestsParkinson Disease/drug therapy/pathologyProspective Studies
Identifiers
PMID: 23238963
Full text
Article (Published version) (3.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Maladie de Parkinson (911)
Citation
(ISO format)
KRAINIK, Alexandre et al. Levodopa does not change cerebral vasoreactivity in Parkinson's disease. In: Movement Disorders, 2013, vol. 28, n° 4, p. 469-75. https://archive-ouverte.unige.ch/unige:33606

253 hits

0 download

Update

Deposited on : 2014-01-23

Export document
Format :
Citation style :