Scientific article

Psychostimulant effect of levodopa: reversing sensitisation is possible

Published inJournal of neurology, neurosurgery and psychiatry, vol. 84, no. 1, p. 18-22
Publication date2013

Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.

  • Anxiety/chemically induced/complications
  • Basal Ganglia/drug effects
  • Deep Brain Stimulation/methods/psychology
  • Depression/chemically induced/complications
  • Dopamine Agonists/adverse effects/therapeutic use
  • Dyskinesia, Drug-Induced/complications/therapy
  • Euphoria/drug effects
  • Female
  • Humans
  • Levodopa/adverse effects/pharmacology
  • Male
  • Middle Aged
  • Motivation/drug effects
  • Parkinson Disease/complications/drug therapy/therapy
  • Psychiatric Status Rating Scales/statistics & numerical data
  • Severity of Illness Index
  • Subthalamic Nucleus/physiology
Citation (ISO format)
CASTRIOTO, Anna et al. Psychostimulant effect of levodopa: reversing sensitisation is possible. In: Journal of neurology, neurosurgery and psychiatry, 2013, vol. 84, n° 1, p. 18–22. doi: 10.1136/jnnp-2012-302444
Main files (1)
Article (Published version)
ISSN of the journal0022-3050

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