Psychostimulant effect of levodopa: reversing sensitisation is possible

Castrioto, Anna; Kistner, Andrea; Klinger, Hélène; Lhommée, Eugénie; Schmitt, Emmanuelle; Fraix, Valérie; Chabardès, Stephan; Mertens, Patrick; Quesada, Jean-Louis; Broussolle, Emmanuel; Pollak, Pierre; Thobois, Stéphane C; Krack, Paul

doi:10.1136/jnnp-2012-302444

Scientific article

English

Psychostimulant effect of levodopa: reversing sensitisation is possible

ContributorsCastrioto, Anna; Kistner, Andrea; Klinger, Hélène; Lhommée, Eugénie; Schmitt, Emmanuelle; Fraix, Valérie; Chabardès, Stephan; Mertens, Patrick; Quesada, Jean-Louis; Broussolle, Emmanuel; Pollak, Pierre; Thobois, Stéphane C; Krack, Paul

Published inJournal of neurology, neurosurgery and psychiatry, vol. 84, no. 1, p. 18-22

Publication date2013

Abstract

Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.

Keywords

Anxiety/chemically induced/complications
Basal Ganglia/drug effects
Deep Brain Stimulation/methods/psychology
Depression/chemically induced/complications
Dopamine Agonists/adverse effects/therapeutic use
Dyskinesia, Drug-Induced/complications/therapy
Euphoria/drug effects
Female
Humans
Levodopa/adverse effects/pharmacology
Male
Middle Aged
Motivation/drug effects
Parkinson Disease/complications/drug therapy/therapy
Psychiatric Status Rating Scales/statistics & numerical data
Severity of Illness Index
Subthalamic Nucleus/physiology

Affiliation

Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

Research group

Maladie de Parkinson (911)

Citation (ISO format)

CASTRIOTO, Anna et al. Psychostimulant effect of levodopa: reversing sensitisation is possible. In: Journal of neurology, neurosurgery and psychiatry, 2013, vol. 84, n° 1, p. 18–22. doi: 10.1136/jnnp-2012-302444

Article (Published version)

Identifiers

PID : unige:33561
DOI : 10.1136/jnnp-2012-302444
PMID : 22991345

ISSN of the journal0022-3050

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Psychostimulant effect of levodopa: reversing sensitisation is possible

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