Scientific article
English

Psychostimulant effect of levodopa: reversing sensitisation is possible

Published in

Journal of neurology, neurosurgery and psychiatry, vol. 84, no. 1, p. 18-22

Publication date

2013

Abstract

Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.

Keywords

  • Anxiety/chemically induced/complications
  • Basal Ganglia/drug effects
  • Deep Brain Stimulation/methods/psychology
  • Depression/chemically induced/complications
  • Dopamine Agonists/adverse effects/therapeutic use
  • Dyskinesia, Drug-Induced/complications/therapy
  • Euphoria/drug effects
  • Female
  • Humans
  • Levodopa/adverse effects/pharmacology
  • Male
  • Middle Aged
  • Motivation/drug effects
  • Parkinson Disease/complications/drug therapy/therapy
  • Psychiatric Status Rating Scales/statistics & numerical data
  • Severity of Illness Index
  • Subthalamic Nucleus/physiology

UNIGE research groups

Citation (ISO format)

CASTRIOTO, Anna et al. Psychostimulant effect of levodopa: reversing sensitisation is possible. In: Journal of neurology, neurosurgery and psychiatry, 2013, vol. 84, n° 1, p. 18–22. doi: 10.1136/jnnp-2012-302444

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0022-3050
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Technical informations

Creation

13/01/2014 18:26:00

First validation

13/01/2014 18:26:00

Update

14/03/2023 20:53:06

Status update

14/03/2023 20:53:06

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30/10/2024 15:59:49
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