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Psychostimulant effect of levodopa: reversing sensitisation is possible

Castrioto, Anna
Kistner, Andrea
Klinger, Hélène
Lhommée, Eugénie
Schmitt, Emmanuelle
Fraix, Valérie
Chabardès, Stephan
Mertens, Patrick
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Published in Journal of neurology, neurosurgery and psychiatry. 2013, vol. 84, no. 1, p. 18-22
Abstract Levodopa therapy in Parkinson's disease (PD) is associated with non-motor complications resulting from sensitisation of the ventral striatum system. Recent studies showed an improvement in non-motor complications in PD patients with subthalamic stimulation. We hypothesised that ventral striatum desensitisation might contribute to this improvement.
Keywords Anxiety/chemically induced/complicationsBasal Ganglia/drug effectsDeep Brain Stimulation/methods/psychologyDepression/chemically induced/complicationsDopamine Agonists/adverse effects/therapeutic useDyskinesia, Drug-Induced/complications/therapyEuphoria/drug effectsFemaleHumansLevodopa/adverse effects/pharmacologyMaleMiddle AgedMotivation/drug effectsParkinson Disease/complications/drug therapy/therapyPsychiatric Status Rating Scales/statistics & numerical dataSeverity of Illness IndexSubthalamic Nucleus/physiology
PMID: 22991345
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Research group Maladie de Parkinson (911)
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CASTRIOTO, Anna et al. Psychostimulant effect of levodopa: reversing sensitisation is possible. In: Journal of neurology, neurosurgery and psychiatry, 2013, vol. 84, n° 1, p. 18-22. doi: 10.1136/jnnp-2012-302444 https://archive-ouverte.unige.ch/unige:33561

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Deposited on : 2014-01-22

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