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DCD Pigs' Kidneys Analyzed by MRI to Assess Ex Vivo Their Viability

Ruttimann, Raphael
Nastasi, Antonio
Published in Transplantation. 2014, vol. 97, no. 2, p. 148-53
Abstract Magnetic resonance imaging (MRI) gadolinium-perfusion was applied in simulated Donation after Cardiac Death (DCD) in porcine kidneys to measure intrarenal perfusion. Adenosine triphosphate (ATP) resynthesis during oxygenated hypothermic perfusion was compared to evaluate the "ex vivo organ viability". Adenine nucleotide (AN) was measured by P nuclear magnetic resonance (NMR) spectroscopy. Whereas this latter technique requires sophisticated hardware, gadolinium-perfusion can be realized using any standard proton-MRI scanner. The aim of this work was to establish a correlation between the two methods.
PMID: 24434482
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) (539)
Analyse protéomique et Analyse génomique des maladies rénales (659)
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BUCHS, Jean-Bernard et al. DCD Pigs' Kidneys Analyzed by MRI to Assess Ex Vivo Their Viability. In: Transplantation, 2014, vol. 97, n° 2, p. 148-53. doi: 10.1097/01.TP.0000438023.02751.22 https://archive-ouverte.unige.ch/unige:33501

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Deposited on : 2014-01-21

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