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Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma

Rappa, Francesca
Greco, Azzura
Podrini, Christine
Cappello, Francesco
Marino, Arianna
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Published in PloS one. 2013, vol. 8, no. 1, e54458
Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important and the identification of specific biomarkers for early diagnosis of HCC represents an active field of research. Increasing evidence indicates that fat accumulation in the liver, defined as hepatosteatosis, is an independent and strong risk factor for developing an HCC. MacroH2A1, a histone protein generally associated with the repressed regions of chromosomes, is involved in hepatic lipid metabolism and is present in two alternative spliced isoforms, macroH2A1.1 and macroH2A1.2. These isoforms have been shown to predict lung and colon cancer recurrence but to our knowledge, their role in fatty-liver associated HCC has not been investigated previously.
Keywords AnimalsBiological Markers/metabolismCarcinoma, Hepatocellular/etiology/genetics/metabolism/pathologyCell Nucleus/genetics/metabolism/pathologyDiet, High-FatDiethylnitrosamineFatty Liver/chemically induced/complications/genetics/metabolismGene Expression RegulationHepatocytes/metabolism/pathologyHistones/genetics/metabolismHumansImmunohistochemistryLiver Neoplasms/etiology/genetics/metabolism/pathologyMaleMiceMice, KnockoutPTEN Phosphohydrolase/deficiency/geneticsProtein Isoforms/genetics/metabolismTumor Microenvironment/genetics
PMID: 23372727
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Research group Obésité et syndrome métabolique (803)
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RAPPA, Francesca et al. Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. In: PloS one, 2013, vol. 8, n° 1, p. e54458. doi: 10.1371/journal.pone.0054458 https://archive-ouverte.unige.ch/unige:33359

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Deposited on : 2014-01-16

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