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EB-D fibronectin expression in squamous cell carcinoma of the head and neck

Ares, Carmen
Published in Oral Oncology. 2005, vol. 41, no. 1, p. 82-8
Abstract ED-B fibronectin (ED-B FN), a glycoprotein involved in cell adhesion and migration, is expressed in fetal and neoplastic tissues and absent in their normal counterparts. The aim of this study is to evaluate the expression of this glycoprotein in relation to the histological and clinical data and to determine whether it has a prognostic value in patients with head and neck squamous cell carcinoma (HNSCC). Ninety-five cases were assessed for ED-B FN expression using immunohistochemistry. Positive ED-B FN expression was significantly associated with tumor grade (p=0.06) and primary tumor site (p=0.02). The larynx was the tumor site associated with the least ED-B FN expression. In univariate analysis, there was no association with disease-free survival (p=0.48), but the mean time to progression was clearly shorter in tumors with positive ED-B FN expression than in those with negative expression (6 vs. 11 months). Patients having tumors expressing the ED-B FN had a trend to a significant lower overall survival in the multivariate analysis (p=0.06). Our study showed that ED-B FN expression might have a prognostic value in patients with HNSCC.
Keywords AdultAgedAged, 80 and overCarcinoma, Squamous Cell/metabolism/pathology/therapyDisease ProgressionFemaleFibronectins/metabolismHead and Neck Neoplasms/metabolism/pathology/therapyHumansImmunoenzyme TechniquesMaleMiddle AgedNeoplasm Proteins/metabolismNeoplasm StagingPrognosisRetrospective StudiesSurvival AnalysisTreatment OutcomeTumor Markers, Biological/metabolism
PMID: 15598590
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Research group Groupe Dulguerov Pavel (ORL et chirurgie cervico-faciale) (145)
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MHAWECH-FAUCEGLIA, Paulette et al. EB-D fibronectin expression in squamous cell carcinoma of the head and neck. In: Oral Oncology, 2005, vol. 41, n° 1, p. 82-8. doi: 10.1016/j.oraloncology.2004.07.003 https://archive-ouverte.unige.ch/unige:33104

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Deposited on : 2014-01-10

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