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Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

ContributorsMarroquin Belaunzaran, Osiris; Cordero, Maria Isabel; Setola, Veronica; Bianchi, Siro; Galli, Carmela; Bouche, Nicolas; Mlynarik, Vladimir; Gruetter, Rolf; Sandi, Carmen; Bensadoun, Jean-Charles; Molinari, Maurizio; Aebischer, Patrick
Published inPloS one, vol. 6, no. 4, e18268
Publication date2011
Abstract

Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current principal disadvantages for broadening their use in clinic.

Keywords
  • Animals
  • Cell Line
  • Immunization, Passive
  • Immunoglobulin Fragments/administration & dosage
  • Mice
Affiliation entities
Research groups
Citation (ISO format)
MARROQUIN BELAUNZARAN, Osiris et al. Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool. In: PloS one, 2011, vol. 6, n° 4, p. e18268. doi: 10.1371/journal.pone.0018268
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Article (Published version)
accessLevelPublic CC BY
Identifiers
Journal ISSN1932-6203
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321downloads

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