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Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats

Cudalbu, Cristina
Comment, Arnaud
Kurdzesau, Fiodar
van Heeswijk, Ruud B
Uffmann, Kai
Jannin, Sami
Denisov, Vladimir
Kirik, Deniz
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Published in Physical Chemistry Chemical Physics. 2010, vol. 12, no. 22, p. 5818-23
Abstract The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo(13)C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized (15)N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized (15)N labeled choline in live animals.
Keywords AnimalsCholine/chemistryIsotope LabelingMagnetic Resonance Imaging/methodsMaleNitrogen Isotopes/chemistryRatsRats, Sprague-Dawley
PMID: 20461252
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CUDALBU, Cristina et al. Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats. In: Physical Chemistry Chemical Physics, 2010, vol. 12, n° 22, p. 5818-23. https://archive-ouverte.unige.ch/unige:32978

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Deposited on : 2014-01-08

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