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Title

Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla
Authors
Cudalbu, Cristina
Mlynárik, Vladimír
Xin, Lijing
Gruetter, Rolf
Published in Magnetic Resonance in Medicine. 2009, vol. 62, no. 4, p. 862-7
Abstract Knowledge of T(1) relaxation times can be important for accurate relative and absolute quantification of brain metabolites, for sensitivity optimizations, for characterizing molecular dynamics, and for studying changes induced by various pathological conditions. (1)H T(1) relaxation times of a series of brain metabolites, including J-coupled ones, were determined using a progressive saturation (PS) technique that was validated with an adiabatic inversion-recovery (IR) method. The (1)H T(1) relaxation times of 16 functional groups of the neurochemical profile were measured at 14.1T and 9.4T. Overall, the T(1) relaxation times found at 14.1T were, within the experimental error, identical to those at 9.4T. The T(1)s of some coupled spin resonances of the neurochemical profile were measured for the first time (e.g., those of gamma-aminobutyrate [GABA], aspartate [Asp], alanine [Ala], phosphoethanolamine [PE], glutathione [GSH], N-acetylaspartylglutamate [NAAG], and glutamine [Gln]). Our results suggest that T(1) does not increase substantially beyond 9.4T. Furthermore, the similarity of T(1) among the metabolites (approximately 1.5 s) suggests that T(1) relaxation time corrections for metabolite quantification are likely to be similar when using rapid pulsing conditions. We therefore conclude that the putative T(1) increase of metabolites has a minimal impact on sensitivity when increasing B(0) beyond 9.4T.
Keywords Algorithms — Animals — Brain/metabolism — Brain Chemistry — Female — Magnetic Resonance Spectroscopy/methods — Rats — Rats, Sprague-Dawley
Identifiers
PMID: 19645007
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Article (Published version) (431 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research group CIBM (863)
Citation
(ISO format) 		CUDALBU, Cristina et al. Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla. In: Magnetic Resonance in Medicine, 2009, vol. 62, n° 4, p. 862-7. doi: 10.1002/mrm.22022 https://archive-ouverte.unige.ch/unige:32966

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Deposited on : 2014-01-08

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