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Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents |
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Published in | Magnetic Resonance in Medicine. 2009, vol. 61, no. 6, p. 1489-93 | |
Abstract | Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging. | |
Keywords | Animals — Brain/metabolism — Contrast Media/analysis/pharmacokinetics — Isotopes/diagnostic use/pharmacokinetics — Lithium/diagnostic use/pharmacokinetics — Magnetic Resonance Spectroscopy/methods — Male — Metabolic Clearance Rate — Molecular Probe Techniques — Molecular Probes — Nanostructures/chemistry — Radiopharmaceuticals/diagnostic use/pharmacokinetics — Rats — Rats, Sprague-Dawley | |
Identifiers | DOI: 10.1002/mrm.21952 PMID: 19353663 | |
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Research group | CIBM (863) | |
Citation (ISO format) | VAN HEESWIJK, Ruud B et al. Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents. In: Magnetic Resonance in Medicine, 2009, vol. 61, n° 6, p. 1489-93. doi: 10.1002/mrm.21952 https://archive-ouverte.unige.ch/unige:32955 |