Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents

van Heeswijk, Ruud B; Uffmann, Kai; Comment, Arnaud; Kurdzesau, Fiodar; Perazzolo, Chiara; Cudalbu, Cristina; Jannin, Sami; Konter, Jacobus A; Hautle, Patrick; van den Brandt, Ben; Navon, Gil; van der Klink, Jacques J; Gruetter, Rolf

doi:10.1002/mrm.21952

Advanced search

Browse by...

Deposit

Highlights

More informations

Title		Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents
Authors		van Heeswijk, Ruud B Uffmann, Kai Comment, Arnaud Kurdzesau, Fiodar Perazzolo, Chiara Cudalbu, Cristina Jannin, Sami Konter, Jacobus A Hautle, Patrick van den Brandt, Ben Navon, Gil van der Klink, Jacques J Gruetter, Rolf show all authors [1 - 13]
Published in		Magnetic Resonance in Medicine. 2009, vol. 61, no. 6, p. 1489-93
Abstract		Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging.
Keywords		Animals — Brain/metabolism — Contrast Media/analysis/pharmacokinetics — Isotopes/diagnostic use/pharmacokinetics — Lithium/diagnostic use/pharmacokinetics — Magnetic Resonance Spectroscopy/methods — Male — Metabolic Clearance Rate — Molecular Probe Techniques — Molecular Probes — Nanostructures/chemistry — Radiopharmaceuticals/diagnostic use/pharmacokinetics — Rats — Rats, Sprague-Dawley
Identifiers		DOI: 10.1002/mrm.21952 PMID: 19353663
Full text		Article (Published version) (337 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research group		CIBM (863)
Citation (ISO format)		VAN HEESWIJK, Ruud B et al. Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents. In: Magnetic Resonance in Medicine, 2009, vol. 61, n° 6, p. 1489-93. doi: 10.1002/mrm.21952 https://archive-ouverte.unige.ch/unige:32955