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Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents

van Heeswijk, Ruud B
Uffmann, Kai
Comment, Arnaud
Kurdzesau, Fiodar
Cudalbu, Cristina
Jannin, Sami
Konter, Jacobus A
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Published in Magnetic Resonance in Medicine. 2009, vol. 61, no. 6, p. 1489-93
Abstract Lithium is widely used in psychotherapy. The (6)Li isotope has a long intrinsic longitudinal relaxation time T(1) on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium-6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium-6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as (6)Li may provide a novel avenue for molecular imaging.
Keywords AnimalsBrain/metabolismContrast Media/analysis/pharmacokineticsIsotopes/diagnostic use/pharmacokineticsLithium/diagnostic use/pharmacokineticsMagnetic Resonance Spectroscopy/methodsMaleMetabolic Clearance RateMolecular Probe TechniquesMolecular ProbesNanostructures/chemistryRadiopharmaceuticals/diagnostic use/pharmacokineticsRatsRats, Sprague-Dawley
PMID: 19353663
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Research group CIBM (863)
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VAN HEESWIJK, Ruud B et al. Hyperpolarized lithium-6 as a sensor of nanomolar contrast agents. In: Magnetic Resonance in Medicine, 2009, vol. 61, n° 6, p. 1489-93. doi: 10.1002/mrm.21952 https://archive-ouverte.unige.ch/unige:32955

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Deposited on : 2014-01-08

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