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Editing through multiple bonds: threonine detection

Marjanska, Malgorzata
Henry, Pierre-Gilles
Uğurbil, Kâmil
Published in Magnetic Resonance in Medicine. 2008, vol. 59, no. 2, p. 245-51
Abstract In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technically challenging. In this study, the threonine signal was detected using a single-shot multiple-bond editing technique and quantified in vivo in both rat and human brains. A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain.
Keywords AnimalsBrain/metabolismHumansHydrogen-Ion ConcentrationLactates/metabolismMagnetic Resonance Spectroscopy/methodsMalePhantoms, ImagingRatsRats, Sprague-DawleyReproducibility of ResultsThreonine/metabolism
PMID: 18228590
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MARJANSKA, Malgorzata et al. Editing through multiple bonds: threonine detection. In: Magnetic Resonance in Medicine, 2008, vol. 59, n° 2, p. 245-51. https://archive-ouverte.unige.ch/unige:32950

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Deposited on : 2014-01-08

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