UNIGE document Scientific Article
previous document  unige:32950  next document
add to browser collection
Title

Editing through multiple bonds: threonine detection

Authors
Marjanska, Malgorzata
Henry, Pierre-Gilles
Uğurbil, Kâmil
Published in Magnetic Resonance in Medicine. 2008, vol. 59, no. 2, p. 245-51
Abstract In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technically challenging. In this study, the threonine signal was detected using a single-shot multiple-bond editing technique and quantified in vivo in both rat and human brains. A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain.
Keywords AnimalsBrain/metabolismHumansHydrogen-Ion ConcentrationLactates/metabolismMagnetic Resonance Spectroscopy/methodsMalePhantoms, ImagingRatsRats, Sprague-DawleyReproducibility of ResultsThreonine/metabolism
Identifiers
PMID: 18228590
Full text
Article (Published version) (459 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group CIBM (863)
Citation
(ISO format)
MARJANSKA, Malgorzata et al. Editing through multiple bonds: threonine detection. In: Magnetic Resonance in Medicine, 2008, vol. 59, n° 2, p. 245-51. https://archive-ouverte.unige.ch/unige:32950

153 hits

0 download

Update

Deposited on : 2014-01-08

Export document
Format :
Citation style :