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Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T.

Xin, Lijing
Gambarota, Giulio
Mlynárik, Vladimír
Published in NMR in Biomedicine. 2008, vol. 21, no. 4, p. 396-401
Abstract Knowledge of proton T2 relaxation time of metabolites is essential for proper quantitation of metabolite concentrations in localized proton spectroscopy, especially at moderate to long TEs. Although the T2 relaxation time of singlets, such as that of creatine and N-acetylaspartate, has been characterized in several studies, similar information is lacking from coupled spin resonances of cerebral metabolites. In this study, the T2 relaxation time of coupled spin resonances and singlet resonances of cerebral metabolites was measured in rat brain in vivo at 9.4 T. Spectra were acquired at 11 TEs using the SPin ECho, full Intensity Acquired Localized (SPECIAL) spectroscopy method. Data analysis was performed in the frequency domain with the LCModel software using simulated TE-specific basis sets. The T2 relaxation times in compounds showing singlet resonances were 113 +/- 3 ms (total creatine), 178 +/- 29 ms (total choline) and 202 +/- 12 ms (N-acetylaspartate). The T2 values of J-coupled metabolites ranged from 89 +/- 8 ms (glutamate) to 148 +/- 14 ms (myo-inositol).
Keywords AnimalsBrain/metabolismComputer SimulationCreatine/metabolismGlutamic Acid/metabolismInositol/metabolismMagnetic Resonance SpectroscopyProtonsRatsRats, Sprague-DawleyTaurine/metabolismTime FactorsWater
PMID: 17907262
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XIN, Lijing et al. Proton T2 relaxation time of J-coupled cerebral metabolites in rat brain at 9.4 T. In: NMR in Biomedicine, 2008, vol. 21, n° 4, p. 396-401. doi: 10.1002/nbm.1205 https://archive-ouverte.unige.ch/unige:32943

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Deposited on : 2014-01-08

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