en
Scientific article
English

Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

Published inJournal of neuroscience research, vol. 85, no. 15, p. 3340-3346
Publication date2007
Abstract

In vivo (1)H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 +/- 0.02 micromol/g during the first half of the stimulation paradigm, to 0.06 +/- 0.02 micromol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed.

Keywords
  • Adaptation, Physiological/physiology
  • Adult
  • Brain Chemistry
  • Humans
  • Lactic Acid/analysis/metabolism
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Oxygen/blood
  • Photic Stimulation
  • Visual Cortex/metabolism
Research group
Citation (ISO format)
MANGIA, Silvia et al. Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli. In: Journal of neuroscience research, 2007, vol. 85, n° 15, p. 3340–3346. doi: 10.1002/jnr.21371
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0360-4012
458views
0downloads

Technical informations

Creation12/16/2013 8:16:00 AM
First validation12/16/2013 8:16:00 AM
Update time03/14/2023 8:48:55 PM
Status update03/14/2023 8:48:55 PM
Last indexation01/16/2024 1:50:46 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack