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Scientific article
Open access
English

Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions

Published inMagnetic resonance imaging, vol. 25, no. 6, p. 821-825
Publication date2007
Abstract

The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM(-1) s(-1), whereas its relaxivity on glutamate C1 and C5 in aqueous solution was approximately 0.5 mM(-1) s(-1). Both relaxivities allow the preparation of solutions with a predetermined short T1 and suggest that in vitro substantial sensitivity gains in their measurement can be achieved. 6Li has a long intrinsic relaxation time, on the order of several minutes, which was strongly affected by the contrast agents. Relaxivity ranged from approximately 0.1 mM(-1) s(-1) for Omniscan to 0.3 for Magnevist, whereas the relaxivity of Gd-DOTP was at 11 mM(-1) s(-1), which is two orders of magnitude higher. Overall, these experiments suggest that the presence of 0.1- to 10-microM contrast agents should be detectable, provided sufficient sensitivity is available, such as that afforded by hyperpolarization, recently introduced to in vivo imaging.

Keywords
  • Carbon Radioisotopes/pharmacology
  • Chelating Agents/chemistry
  • Contrast Media/pharmacology
  • Formates/chemistry
  • Gadolinium/pharmacology
  • Image Processing, Computer-Assisted
  • Lithium/pharmacology
  • Magnetic Resonance Imaging/instrumentation/methods
  • Nanoparticles/chemistry
  • Organometallic Compounds/chemistry
  • Sensitivity and Specificity
  • Solutions
  • Water/chemistry
Research group
Citation (ISO format)
VAN HEESWIJK, Ruud B et al. Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions. In: Magnetic resonance imaging, 2007, vol. 25, n° 6, p. 821–825. doi: 10.1016/j.mri.2007.02.015
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Article (Published version)
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Identifiers
ISSN of the journal0730-725X
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