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Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions

van Heeswijk, Ruud B
Published in Magnetic Resonance Imaging. 2007, vol. 25, no. 6, p. 821-5
Abstract The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM(-1) s(-1), whereas its relaxivity on glutamate C1 and C5 in aqueous solution was approximately 0.5 mM(-1) s(-1). Both relaxivities allow the preparation of solutions with a predetermined short T1 and suggest that in vitro substantial sensitivity gains in their measurement can be achieved. 6Li has a long intrinsic relaxation time, on the order of several minutes, which was strongly affected by the contrast agents. Relaxivity ranged from approximately 0.1 mM(-1) s(-1) for Omniscan to 0.3 for Magnevist, whereas the relaxivity of Gd-DOTP was at 11 mM(-1) s(-1), which is two orders of magnitude higher. Overall, these experiments suggest that the presence of 0.1- to 10-microM contrast agents should be detectable, provided sufficient sensitivity is available, such as that afforded by hyperpolarization, recently introduced to in vivo imaging.
Keywords Carbon Radioisotopes/pharmacologyChelating Agents/chemistryContrast Media/pharmacologyFormates/chemistryGadolinium/pharmacologyImage Processing, Computer-AssistedLithium/pharmacologyMagnetic Resonance Imaging/instrumentation/methodsNanoparticles/chemistryOrganometallic Compounds/chemistrySensitivity and SpecificitySolutionsWater/chemistry
PMID: 17448617
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Research group CIBM (863)
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VAN HEESWIJK, Ruud B et al. Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions. In: Magnetic Resonance Imaging, 2007, vol. 25, n° 6, p. 821-5. doi: 10.1016/j.mri.2007.02.015 https://archive-ouverte.unige.ch/unige:32927

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Deposited on : 2014-01-08

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