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In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

ContributorsHenry, Pierre-Gilles; Adriany, Gregor; Deelchand, Dinesh; Gruetter, Rolf; Marjanska, Malgorzata; Oz, Gülin; Seaquist, Elizabeth R; Shestov, Alexander; Uğurbil, Kâmil
Published inMagnetic resonance imaging, vol. 24, no. 4, p. 527-539
Publication date2006
Abstract

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Keywords
  • Animals
  • Brain/metabolism
  • Carbon Radioisotopes
  • Magnetic Resonance Spectroscopy
  • Models, Biological
  • Rats
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Research groups
Citation (ISO format)
HENRY, Pierre-Gilles et al. In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective. In: Magnetic resonance imaging, 2006, vol. 24, n° 4, p. 527–539. doi: 10.1016/j.mri.2006.01.003
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accessLevelRestricted
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Journal ISSN0730-725X
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