In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

Henry, Pierre-Gilles; Adriany, Gregor; Deelchand, Dinesh; Gruetter, Rolf; Marjanska, Malgorzata; Oz, Gülin; Seaquist, Elizabeth R; Shestov, Alexander; Uğurbil, Kâmil

doi:10.1016/j.mri.2006.01.003

Scientific article

English

In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

ContributorsHenry, Pierre-Gilles; Adriany, Gregor; Deelchand, Dinesh; Gruetter, Rolf; Marjanska, Malgorzata; Oz, Gülin; Seaquist, Elizabeth R; Shestov, Alexander; Uğurbil, Kâmil

Published inMagnetic resonance imaging, vol. 24, no. 4, p. 527-539

Publication date2006

Abstract

In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Keywords

Animals
Brain/metabolism
Carbon Radioisotopes
Magnetic Resonance Spectroscopy
Models, Biological
Rats

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research groups

CIBM (863)

Citation (ISO format)

HENRY, Pierre-Gilles et al. In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective. In: Magnetic resonance imaging, 2006, vol. 24, n° 4, p. 527–539. doi: 10.1016/j.mri.2006.01.003

Article (Published version)

Identifiers

PID : unige:32916
DOI : 10.1016/j.mri.2006.01.003
PMID : 16677959

Journal ISSN0730-725X

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In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

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