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Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T.

Mangia, Silvia
Tkác, Ivan
Van De Moortele, Pierre-Francois
Giove, Federico
Maraviglia, Bruno
Uğurbil, Kâmil
Published in Magnetic Resonance Imaging. 2006, vol. 24, no. 4, p. 343-8
Abstract Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of 1H-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 micromol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (+/-0.2 micromol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz.
Keywords HumansMagnetic Resonance Spectroscopy/methods/statistics & numerical dataProtonsSensitivity and SpecificityVisual Cortex/metabolism
PMID: 16677939
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Research group CIBM (863)
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MANGIA, Silvia et al. Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T. In: Magnetic Resonance Imaging, 2006, vol. 24, n° 4, p. 343-8. doi: 10.1016/j.mri.2005.12.023 https://archive-ouverte.unige.ch/unige:32913

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Deposited on : 2014-01-08

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