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Scientific article
Case report
English

Sleep induced by stimulation in the human pedunculopontine nucleus area

Contributors

Arnulf, Isabelle; Ferraye, Muriel; Fraix, Valérie; Benabid, Alim Louis; Chabardès, Stephan; Goetz, Laurent; Pollak, Pierre; Debû, Bettina

Published in

Annals of neurology, vol. 67, no. 4, p. 546-549

Publication date

2010

Abstract

The pedunculopontine nucleus is part of the reticular ascending arousal system and is involved in locomotion and sleep. Two patients with Parkinson disease received electrodes that stimulated the pedunculopontine nucleus area to alleviate their severe gait impairment. Instead, we found that low-frequency stimulation of the pedunculopontine nucleus area increased alertness, whereas high-frequency stimulation induced non-rapid eye movement sleep. In addition, the sudden withdrawal of the low-frequency stimulation was consistently followed by rapid eye movement sleep episodes in 1 patient. These data have the potential to benefit patients who suffer from sleep disorders.

Keywords

  • Aged
  • Electric Stimulation/adverse effects
  • Humans
  • Middle Aged
  • Parkinson Disease/therapy
  • Pedunculopontine Tegmental Nucleus/physiology
  • Sleep Disorders/etiology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

ARNULF, Isabelle et al. Sleep induced by stimulation in the human pedunculopontine nucleus area. In: Annals of neurology, 2010, vol. 67, n° 4, p. 546–549. doi: 10.1002/ana.21912

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0364-5134
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Technical informations

Creation

03/01/2014 12:01:00

First validation

03/01/2014 12:01:00

Update

14/03/2023 20:48:27

Status update

14/03/2023 20:48:27

Last indexation

30/10/2024 15:41:27
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