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Handwriting in patients with Parkinson disease: effect of L-dopa and stimulation of the sub-thalamic nucleus on motor anticipation

Bidet-Ildei, Christel
Kandel, Sonia
Fraix, Valérie
Orliaguet, Jean-Pierre
Published in Human movement science. 2011, vol. 30, no. 4, p. 783-91
Abstract The present research focused on how patients with Parkinson's disease (PD) produce handwriting sequences. PD patients who were on/off medication or deep brain stimulation treatments had to write lll and lln trigrams. We evaluated their ability to anticipate on-line the last letter in the trigram. The results revealed that in PD patients, contrary to healthy participants, the percentage of time taken by the down-stroke of the second l did not vary as a function of the spatial constraints of the following letter (l or n). In other words, the handwriting of the PD patients did not exhibit any sign of motor anticipation. However, under treatment, PD patients exhibited similar results to healthy participants despite no improvement in movement variability. Taken together these results do not seem consistent with the hypothesis that PD patients do not anticipate future movements because of their movement variability. They are more in agreement with theories that postulate that PD patients have a general deficit in the parallel processing of the components of a motor sequence.
Keywords AdultAnticipation, Psychological/drug effects/physiologyAntiparkinson Agents/therapeutic useAttention/drug effects/physiologyComputer GraphicsDeep Brain StimulationFemaleHandwritingHumansLevodopa/therapeutic useMaleMiddle AgedNeurologic Examination/drug effectsParkinson Disease/diagnosis/drug therapy/physiopathologyPsychomotor Performance/drug effects/physiologyReaction Time/drug effects/physiologyReference ValuesSubthalamic Nucleus/physiology
PMID: 21339012
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Research group Maladie de Parkinson (911)
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BIDET-ILDEI, Christel et al. Handwriting in patients with Parkinson disease: effect of L-dopa and stimulation of the sub-thalamic nucleus on motor anticipation. In: Human movement science, 2011, vol. 30, n° 4, p. 783-91. doi: 10.1016/j.humov.2010.08.008 https://archive-ouverte.unige.ch/unige:32862

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Deposited on : 2014-01-07

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