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Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease

Piallat, Brigitte
Polosan, Mircea
Fraix, Valérie
Goetz, Laurent
David, Olivier
Fenoy, Albert
Torres, Napoleon
Quesada, Jean-Louis
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Published in Annals of Neurology. 2011, vol. 69, no. 5, p. 793-802
Abstract Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder.
Keywords Action Potentials/physiologyAdultAgedFemaleFunctional Laterality/physiologyHumansImaging, Three-Dimensional/methodsMagnetic Resonance Imaging/methodsMaleMiddle AgedNeurons/physiologyObsessive-Compulsive Disorder/pathologyParkinson Disease/pathologySubthalamic Nucleus/pathology
PMID: 21520240
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Research group Maladie de Parkinson (911)
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PIALLAT, Brigitte et al. Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease. In: Annals of Neurology, 2011, vol. 69, n° 5, p. 793-802. doi: 10.1002/ana.22222 https://archive-ouverte.unige.ch/unige:32861

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Deposited on : 2014-01-07

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