UNIGE document Scientific Article
previous document  unige:32861  next document
add to browser collection
Title

Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease

Authors
Piallat, Brigitte
Polosan, Mircea
Fraix, Valérie
Goetz, Laurent
David, Olivier
Fenoy, Albert
Torres, Napoleon
Quesada, Jean-Louis
show hidden authors show all authors [1 - 14]
Published in Annals of Neurology. 2011, vol. 69, no. 5, p. 793-802
Abstract Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder.
Keywords Action Potentials/physiologyAdultAgedFemaleFunctional Laterality/physiologyHumansImaging, Three-Dimensional/methodsMagnetic Resonance Imaging/methodsMaleMiddle AgedNeurons/physiologyObsessive-Compulsive Disorder/pathologyParkinson Disease/pathologySubthalamic Nucleus/pathology
Identifiers
PMID: 21520240
Full text
Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Maladie de Parkinson (911)
Citation
(ISO format)
PIALLAT, Brigitte et al. Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease. In: Annals of Neurology, 2011, vol. 69, n° 5, p. 793-802. https://archive-ouverte.unige.ch/unige:32861

172 hits

0 download

Update

Deposited on : 2014-01-07

Export document
Format :
Citation style :