en
Scientific article
English

Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease

Published inAnnals of neurology, vol. 69, no. 5, p. 793-802
Publication date2011
Abstract

Although electrophysiologic dysfunction of the subthalamic nucleus is putative, deep brain stimulation of this structure has recently been reported to improve obsessions and compulsions. In Parkinson disease, sensorimotor subthalamic neurons display high-frequency burst firing, which is considered as an electrophysiologic signature of motor loop dysfunction. We addressed whether such neuronal dysfunction of the subthalamic nucleus also exists in the nonmotor loops involved in patients with obsessive-compulsive disorder.

Keywords
  • Action Potentials/physiology
  • Adult
  • Aged
  • Female
  • Functional Laterality/physiology
  • Humans
  • Imaging, Three-Dimensional/methods
  • Magnetic Resonance Imaging/methods
  • Male
  • Middle Aged
  • Neurons/physiology
  • Obsessive-Compulsive Disorder/pathology
  • Parkinson Disease/pathology
  • Subthalamic Nucleus/pathology
Citation (ISO format)
PIALLAT, Brigitte et al. Subthalamic neuronal firing in obsessive-compulsive disorder and Parkinson disease. In: Annals of neurology, 2011, vol. 69, n° 5, p. 793–802. doi: 10.1002/ana.22222
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0364-5134
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