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Scientific article
English

Asymmetric Conjugate Addition to α-Substituted Enones/Enolate Trapping

Published inOrganic letters, vol. 16, no. 1, p. 118-121
Publication date2014
Abstract

An NHC–Cu complex catalyzed the asymmetric conjugate addition (ACA) of various Grignard reagents to nonactivated α-substituted cyclic enones to give 2,3-dialkylated cyclopentanones and cyclohexanones. The Michael addition features the formation of a magnesium enolate intermediate. One-pot diastereoselective trapping of this enolate by alkyl, propargyl, allyl, and benzyl halides led to ketones with contiguous α-quaternary and β-tertiary centers.

Citation (ISO format)
GERMAIN, Nicolas et al. Asymmetric Conjugate Addition to α-Substituted Enones/Enolate Trapping. In: Organic letters, 2014, vol. 16, n° 1, p. 118–121. doi: 10.1021/ol403104s
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ISSN of the journal1523-7052
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Creation01/06/2014 3:43:00 PM
First validation01/06/2014 3:43:00 PM
Update time03/14/2023 8:48:05 PM
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