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Traitement des épilepsies réfractaires : rôle de la stimulation électrique

Rossetti, Andrea O
Published in Revue médicale suisse. 2012, vol. 8, no. 339, p. 930,932-4
Abstract Antiepileptic drugs allow controlling seizures in 70% of patients. For the others, a presurgical work-up should be undertaken, especially if a focal seizure origin is suspected; however, only a fraction of pharmacoresistant patients will be offered resective (curative) surgery. In the last 15 years, several palliative therapies using extra- or intracranial electrical stimulations have been developed. This article presents the vagal nerve stimulation, the deep brain stimulation (targeting the mesiotemporal region or the thalamus), and the cortical stimulation "on demand". All show an overall long-term responder rate between 30-50%, but less than 5% of patients becoming seizure free. It is to hope that a better understanding of epileptogenic mechanisms and of the implicated neuronal networks will lead to an improvement of these proportions.
Keywords Anticonvulsants/therapeutic useDeep Brain Stimulation/methods/utilizationDrug Resistance/physiologyElectric Stimulation/methodsEpilepsy/drug therapyHumansNeurosurgical ProceduresTreatment FailureVagus Nerve Stimulation/methods/utilization
PMID: 22675822
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Other version: http://rms.medhyg.ch/numero-339-page-930.htm
Research groups Epilepsie et Chirurgie (149)
Epilepsie et réseaux cérébraux (1002)
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ROSSETTI, Andrea O, VULLIEMOZ, Serge. Traitement des épilepsies réfractaires : rôle de la stimulation électrique. In: Revue médicale suisse, 2012, vol. 8, n° 339, p. 930,932-4. https://archive-ouverte.unige.ch/unige:32841

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Deposited on : 2014-01-07

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