en
Scientific article
French

Traitement des épilepsies réfractaires : rôle de la stimulation électrique

Published inRevue médicale suisse, vol. 8, no. 339, p. 930,932-934
Publication date2012
Abstract

Antiepileptic drugs allow controlling seizures in 70% of patients. For the others, a presurgical work-up should be undertaken, especially if a focal seizure origin is suspected; however, only a fraction of pharmacoresistant patients will be offered resective (curative) surgery. In the last 15 years, several palliative therapies using extra- or intracranial electrical stimulations have been developed. This article presents the vagal nerve stimulation, the deep brain stimulation (targeting the mesiotemporal region or the thalamus), and the cortical stimulation "on demand". All show an overall long-term responder rate between 30-50%, but less than 5% of patients becoming seizure free. It is to hope that a better understanding of epileptogenic mechanisms and of the implicated neuronal networks will lead to an improvement of these proportions.

Keywords
  • Anticonvulsants/therapeutic use
  • Deep Brain Stimulation/methods/utilization
  • Drug Resistance/physiology
  • Electric Stimulation/methods
  • Epilepsy/drug therapy
  • Humans
  • Neurosurgical Procedures
  • Treatment Failure
  • Vagus Nerve Stimulation/methods/utilization
Citation (ISO format)
ROSSETTI, Andrea O, VULLIEMOZ, Serge. Traitement des épilepsies réfractaires : rôle de la stimulation électrique. In: Revue médicale suisse, 2012, vol. 8, n° 339, p. 930,932–934.
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1660-9379
438views
1downloads

Technical informations

Creation01/03/2014 9:52:00 AM
First validation01/03/2014 9:52:00 AM
Update time03/14/2023 8:48:04 PM
Status update03/14/2023 8:48:04 PM
Last indexation05/02/2024 1:40:04 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack