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Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis |
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Published in | Journal of neuroinflammation. 2011, vol. 8, 161 | |
Abstract | Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS). Establishing the pathological relevance and validity of anti-MOG antibodies as biomarkers has yielded conflicting reports mainly due to different MOG isoforms used in different studies. Because epitope specificity may be a key factor determining anti-MOG reactivity we aimed at identifying a priori immunodominant MOG epitopes by monoclonal antibodies (mAbs) and at assessing clinical relevance of these epitopes in MS. | |
Keywords | Animals — Antibodies, Monoclonal/blood/immunology — Antibody Formation/immunology — Autoantibodies/blood/immunology — Biological Markers/metabolism — Disease Models, Animal — Epitopes/immunology — Humans — Immunodominant Epitopes/immunology — Mice — Multiple Sclerosis/blood/immunology — Myelin Proteins/chemistry/genetics/immunology — Myelin-Oligodendrocyte Glycoprotein — Protein Conformation — Protein Isoforms/chemistry/genetics/immunology | |
Identifiers | PMID: 22093619 | |
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Research group | Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843) | |
Citation (ISO format) | MENGE, Til et al. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. In: Journal of neuroinflammation, 2011, vol. 8, p. 161. doi: 10.1186/1742-2094-8-161 https://archive-ouverte.unige.ch/unige:32727 |