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Title

Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis

Authors
Menge, Til
von Büdingen, H Christian
Genain, Claude P
Published in Journal of Neuroinflammation. 2011, vol. 8, p. 161
Abstract Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS). Establishing the pathological relevance and validity of anti-MOG antibodies as biomarkers has yielded conflicting reports mainly due to different MOG isoforms used in different studies. Because epitope specificity may be a key factor determining anti-MOG reactivity we aimed at identifying a priori immunodominant MOG epitopes by monoclonal antibodies (mAbs) and at assessing clinical relevance of these epitopes in MS.
Keywords AnimalsAntibodies, Monoclonal/blood/immunologyAntibody Formation/immunologyAutoantibodies/blood/immunologyBiological Markers/metabolismDisease Models, AnimalEpitopes/immunologyHumansImmunodominant Epitopes/immunologyMiceMultiple Sclerosis/blood/immunologyMyelin Proteins/chemistry/genetics/immunologyMyelin-Oligodendrocyte GlycoproteinProtein ConformationProtein Isoforms/chemistry/genetics/immunology
Identifiers
PMID: 22093619
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Article (Published version) (876 Kb) - public document Free access
Structures
Research group Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
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(ISO format)
MENGE, Til et al. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. In: Journal of Neuroinflammation, 2011, vol. 8, p. 161. https://archive-ouverte.unige.ch/unige:32727

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Deposited on : 2014-01-02

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