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Scientific article
Open access
English

Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis

Published inJournal of neuroinflammation, vol. 8, 161
Publication date2011
Abstract

Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS). Establishing the pathological relevance and validity of anti-MOG antibodies as biomarkers has yielded conflicting reports mainly due to different MOG isoforms used in different studies. Because epitope specificity may be a key factor determining anti-MOG reactivity we aimed at identifying a priori immunodominant MOG epitopes by monoclonal antibodies (mAbs) and at assessing clinical relevance of these epitopes in MS.

Keywords
  • Animals
  • Antibodies, Monoclonal/blood/immunology
  • Antibody Formation/immunology
  • Autoantibodies/blood/immunology
  • Biological Markers/metabolism
  • Disease Models, Animal
  • Epitopes/immunology
  • Humans
  • Immunodominant Epitopes/immunology
  • Mice
  • Multiple Sclerosis/blood/immunology
  • Myelin Proteins/chemistry/genetics/immunology
  • Myelin-Oligodendrocyte Glycoprotein
  • Protein Conformation
  • Protein Isoforms/chemistry/genetics/immunology
Citation (ISO format)
MENGE, Til et al. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. In: Journal of neuroinflammation, 2011, vol. 8, p. 161. doi: 10.1186/1742-2094-8-161
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Article (Published version)
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Identifiers
ISSN of the journal1742-2094
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