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Title

Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis
Authors
Menge, Til
Lalive d'Epinay, Patrice
von Büdingen, H Christian
Genain, Claude P
Published in Journal of neuroinflammation. 2011, vol. 8, 161
Abstract Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS). Establishing the pathological relevance and validity of anti-MOG antibodies as biomarkers has yielded conflicting reports mainly due to different MOG isoforms used in different studies. Because epitope specificity may be a key factor determining anti-MOG reactivity we aimed at identifying a priori immunodominant MOG epitopes by monoclonal antibodies (mAbs) and at assessing clinical relevance of these epitopes in MS.
Keywords Animals — Antibodies, Monoclonal/blood/immunology — Antibody Formation/immunology — Autoantibodies/blood/immunology — Biological Markers/metabolism — Disease Models, Animal — Epitopes/immunology — Humans — Immunodominant Epitopes/immunology — Mice — Multiple Sclerosis/blood/immunology — Myelin Proteins/chemistry/genetics/immunology — Myelin-Oligodendrocyte Glycoprotein — Protein Conformation — Protein Isoforms/chemistry/genetics/immunology
Identifiers
PMID: 22093619
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Article (Published version) (876 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Citation
(ISO format) 		MENGE, Til et al. Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis. In: Journal of neuroinflammation, 2011, vol. 8, p. 161. doi: 10.1186/1742-2094-8-161 https://archive-ouverte.unige.ch/unige:32727

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Deposited on : 2014-01-02

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