Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children

Lalive d'Epinay, Patrice; Häusler, M G; Maurey, H; Mikaeloff, Y; Tardieu, M; Wiendl, H; Schroeter, M; Hartung, H P; Kieseier, B C; Menge, T

doi:10.1177/1352458510389220

Scientific article

English

Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children

ContributorsLalive d'Epinay, Patrice; Häusler, M G; Maurey, H; Mikaeloff, Y; Tardieu, M; Wiendl, H; Schroeter, M; Hartung, H P; Kieseier, B C; Menge, T

Published inMultiple sclerosis, vol. 17, no. 3, p. 297-302

Publication date2011

Abstract

Myelin oligodendrocyte glycoprotein (MOG) may be implicated in the immunopathogenesis of multiple sclerosis (MS) inducing demyelination in the animal model of MS. In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls.

Keywords

Adolescent
Autoantibodies/blood
Biological Markers/blood
Chi-Square Distribution
Child
Child, Preschool
Demyelinating Diseases/diagnosis/immunology
Diagnosis, Differential
Encephalitis, Viral/diagnosis/immunology
Encephalomyelitis, Acute Disseminated/diagnosis/immunology
Enzyme-Linked Immunosorbent Assay
Epstein-Barr Virus Infections/diagnosis/immunology
Female
Flow Cytometry
France
Germany
Humans
Immunity, Humoral
Male
Myelin Basic Protein
Myelin Proteins
Myelin-Associated Glycoprotein/immunology
Myelin-Oligodendrocyte Glycoprotein
Nerve Tissue Proteins/immunology
Predictive Value of Tests
Retrospective Studies
Transcription Factors/immunology

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)

Citation (ISO format)

LALIVE D’EPINAY, Patrice et al. Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children. In: Multiple sclerosis, 2011, vol. 17, n° 3, p. 297–302. doi: 10.1177/1352458510389220

Article (Published version)

Identifiers

PID : unige:32725
DOI : 10.1177/1352458510389220
PMID : 21177754

Journal ISSN1352-4585

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Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children

Myelin oligodendrocyte glycoprotein (MOG) may be implicated in the immunopathogenesis of multiple sclerosis (MS) inducing demyelination in the animal model of MS. In adults reported anti-MOG antibody frequencies have been variable across a number of studies and can also be detected in controls.

Technical informations