The results of the fracture risk assessment tool (FRAX) could be modulated. Calcium supplements are still in the middle of a cardiovascular controversy. New immunological properties of vitamin D are reported. Denosumab is effective for the prevention of all fractures and can be used without renal limitation. Atypical subtrochanteric femoral fractures are more frequent in case of treatment with bisphosphonates. The teriparatide is effective in various bone diseases. Bazedoxifene, a new SERM is now available. A meta-analysis fails to demonstrate the effectiveness of vertebroplasty on pain relief in case of osteoporotic vertebral fractures.