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Scientific article
English

Copper-Free Asymmetric Allylic Alkylation of Trisubstituted Cyclic Allyl Bromides Using Grignard Reagents

Published inAngewandte Chemie. International edition in English, vol. 52, no. 51, p. 13642-13646
Publication date2013
Abstract

AAA: The asymmetric allylic alkylation (AAA) of trisubstituted cyclic allyl bromides with Grignard reagents is catalytic (2 mol % of ligand) and regioselective (SN2'/SN2=91:9→100:0). The quaternary carbon centers are formed with good to high enantioselectivity (e.r.=81.5:19.5→96:4).

Keywords
  • Quaternary stereocenters
  • Allyl bromides
  • Asymmetric catalysis
  • Diaminocarbenes
  • Grignard reaction
Research group
Citation (ISO format)
GRASSI, David, ALEXAKIS, Alexandre. Copper-Free Asymmetric Allylic Alkylation of Trisubstituted Cyclic Allyl Bromides Using Grignard Reagents. In: Angewandte Chemie. International edition in English, 2013, vol. 52, n° 51, p. 13642–13646. doi: 10.1002/anie.201307591
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ISSN of the journal0570-0833
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Creation12/18/2013 9:21:00 AM
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