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Copper-Free Asymmetric Allylic Alkylation of Trisubstituted Cyclic Allyl Bromides Using Grignard Reagents

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Published in Angewandte Chemie: International Edition in English. 2013, vol. 52, no. 51, p. 13642-13646
Abstract AAA: The asymmetric allylic alkylation (AAA) of trisubstituted cyclic allyl bromides with Grignard reagents is catalytic (2 mol % of ligand) and regioselective (SN2'/SN2=91:9→100:0). The quaternary carbon centers are formed with good to high enantioselectivity (e.r.=81.5:19.5→96:4).
Keywords Quaternary stereocentersAllyl bromidesAsymmetric catalysisDiaminocarbenesGrignard reaction
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Research group Groupe Alexakis
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GRASSI, David, ALEXAKIS, Alexandre. Copper-Free Asymmetric Allylic Alkylation of Trisubstituted Cyclic Allyl Bromides Using Grignard Reagents. In: Angewandte Chemie: International Edition in English, 2013, vol. 52, n° 51, p. 13642-13646. https://archive-ouverte.unige.ch/unige:32651

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Deposited on : 2013-12-23

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