Serious infections in patients with ankylosing spondylitis with and without TNF blockers: a systematic review and meta-analysis of randomised placebo-controlled trials

Fouque-Aubert, Anne; Jette-Paulin, Laetitia; Combescure, Christophe; Basch, André; Tebib, Jacques; Gossec, Laure

doi:10.1136/ard.2008.098822

Scientific article

English

Serious infections in patients with ankylosing spondylitis with and without TNF blockers: a systematic review and meta-analysis of randomised placebo-controlled trials

ContributorsFouque-Aubert, Anne; Jette-Paulin, Laetitia; Combescure, Christophe

; Basch, André; Tebib, Jacques; Gossec, Laure

Published inAnnals of the rheumatic diseases, vol. 69, no. 10, p. 1756-1761

Publication date2010

Abstract

Tumour necrosis factor (TNF) blockers are known to increase the risk of serious infections in rheumatoid arthritis. Despite wide use of TNF blockers in ankylosing spondylitis (AS), the infection risk has never been evaluated in this disease.

Keywords

Antirheumatic Agents/adverse effects
Humans
Opportunistic Infections/complications/epidemiology
Randomized Controlled Trials as Topic
Risk Assessment/methods
Spondylitis, Ankylosing/complications/drug therapy/epidemiology
Tumor Necrosis Factor-alpha/antagonists & inhibitors

Affiliation entities

Faculté de médecine / Section de médecine clinique

Research groups

Epidémiologie clinique (115)

Citation (ISO format)

FOUQUE-AUBERT, Anne et al. Serious infections in patients with ankylosing spondylitis with and without TNF blockers: a systematic review and meta-analysis of randomised placebo-controlled trials. In: Annals of the rheumatic diseases, 2010, vol. 69, n° 10, p. 1756–1761. doi: 10.1136/ard.2008.098822

Article (Published version)

Identifiers

PID : unige:32564
DOI : 10.1136/ard.2008.098822
PMID : 19640854

Journal ISSN0003-4967

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Serious infections in patients with ankylosing spondylitis with and without TNF blockers: a systematic review and meta-analysis of randomised placebo-controlled trials

Tumour necrosis factor (TNF) blockers are known to increase the risk of serious infections in rheumatoid arthritis. Despite wide use of TNF blockers in ankylosing spondylitis (AS), the infection risk has never been evaluated in this disease.

Technical informations