en
Scientific article
Editorial
Open access
English

Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action

Published inAntimicrobial resistance and infection control, vol. 1, no. 1, 11
Publication date2012
Abstract

Resistance to antibiotics has increased dramatically over the past few years and has now reached a level that places future patients in real danger. Microorganisms such as Escherichia coli and Klebsiella pneumoniae, which are commensals and pathogens for humans and animals, have become increasingly resistant to third-generation cephalosporins. Moreover, in certain countries, they are also resistant to carbapenems and therefore susceptible only to tigecycline and colistin. Resistance is primarily attributed to the production of beta-lactamase genes located on mobile genetic elements, which facilitate their transfer between different species. In some rare cases, Gram-negative rods are resistant to virtually all known antibiotics. The causes are numerous, but the role of the overuse of antibiotics in both humans and animals is essential, as well as the transmission of these bacteria in both the hospital and the community, notably via the food chain, contaminated hands, and between animals and humans. In addition, there are very few new antibiotics in the pipeline, particularly for Gram-negative bacilli. The situation is slightly better for Gram-positive cocci as some potent and novel antibiotics have been made available in recent years. A strong and coordinated international programme is urgently needed. To meet this challenge, 70 internationally recognized experts met for a two-day meeting in June 2011 in Annecy (France) and endorsed a global call to action ("The Pensières Antibiotic Resistance Call to Action"). Bundles of measures that must be implemented simultaneously and worldwide are presented in this document. In particular, antibiotics, which represent a treasure for humanity, must be protected and considered as a special class of drugs.

Citation (ISO format)
CARLET, Jean et al. Ready for a world without antibiotics? The Pensières Antibiotic Resistance Call to Action. In: Antimicrobial resistance and infection control, 2012, vol. 1, n° 1, p. 11. doi: 10.1186/2047-2994-1-11
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal2047-2994
591views
445downloads

Technical informations

Creation11/14/2013 12:25:00 PM
First validation11/14/2013 12:25:00 PM
Update time03/14/2023 8:45:50 PM
Status update03/14/2023 8:45:50 PM
Last indexation05/02/2024 1:37:49 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack