UNIGE document Scientific Article - Review
previous document  unige:32494  next document
add to browser collection

Leptin revisited: its mechanism of action and potential for treating diabetes

Bjørbæk, Christian
Published in Nature Reviews Drug Discovery. 2012, vol. 11, no. 9, p. 692-708
Abstract Since the discovery of leptin in 1994, we now have a better understanding of the cellular and molecular mechanisms underlying its biological effects. In addition to its established anti-obesity effects, leptin exerts antidiabetic actions that are independent of its regulation of body weight and food intake. In particular, leptin can correct diabetes in animal models of type 1 and type 2 diabetes. In addition, long-term leptin replacement therapy improves glycaemic control, insulin sensitivity and plasma triglycerides in patients with severe insulin resistance due to lipodystrophy. These results have spurred enthusiasm for the use of leptin therapy to treat diabetes. Here, we review the current understanding of the glucoregulatory functions of leptin, emphasizing its central mechanisms of action and lessons learned from clinical studies, and discuss possible therapeutic applications of leptin in the treatment of type 1 and type 2 diabetes.
Keywords AnimalsBlood Glucose/drug effects/metabolismDiabetes Mellitus/drug therapy/metabolismHumansLeptin/metabolism/pharmacology/therapeutic usePro-Opiomelanocortin/metabolismTreatment Outcome
PMID: 22935803
Full text
Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Coppari Roberto (physiologie cellulaire et métabolisme) (921)
(ISO format)
COPPARI, Roberto, BJØRBÆK, Christian. Leptin revisited: its mechanism of action and potential for treating diabetes. In: Nature Reviews Drug Discovery, 2012, vol. 11, n° 9, p. 692-708. https://archive-ouverte.unige.ch/unige:32494

249 hits



Deposited on : 2013-12-18

Export document
Format :
Citation style :