EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis

Gerlag, Danielle M; Raza, Karim; van Baarsen, Lisa G M; Brouwer, Elisabeth; Buckley, Christopher D; Burmester, Gerd R; Gabay, Cem; Catrina, Anca I; Cope, Andrew P; Cornelis, François; Dahlqvist, Solbritt Rantapää; Emery, Paul; Eyre, Stephen; Finckh, Axel; Gay, Steffen; Hazes, Johanna M; van der Helm-van Mil, Annette; Huizinga, Tom W J; Klareskog, Lars; Kvien, Tore K; Lewis, Cathryn; Machold, Klaus P; Rönnelid, Johan; van Schaardenburg, Dirkjan; Schett, Georg; Smolen, Josef S; Thomas, Sue; Worthington, Jane; Tak, Paul P

doi:10.1136/annrheumdis-2011-200990

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Title		EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis
Authors		Gerlag, Danielle M Raza, Karim van Baarsen, Lisa G M Brouwer, Elisabeth Buckley, Christopher D Burmester, Gerd R Gabay, Cem Catrina, Anca I Cope, Andrew P Cornelis, François Dahlqvist, Solbritt Rantapää Emery, Paul Eyre, Stephen Finckh, Axel Gay, Steffen Hazes, Johanna M van der Helm-van Mil, Annette Huizinga, Tom W J Klareskog, Lars Kvien, Tore K Lewis, Cathryn Machold, Klaus P Rönnelid, Johan van Schaardenburg, Dirkjan Schett, Georg Smolen, Josef S Thomas, Sue Worthington, Jane Tak, Paul P show all authors [1 - 29]
Published in		Annals of the Rheumatic Diseases. 2012, vol. 71, no. 5, p. 638-41
Abstract		The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR Standing Committee on Investigative Rheumatology to facilitate research into the preclinical and earliest clinically apparent phases of rheumatoid arthritis (RA). This report describes the recommendation for terminology to be used to define specific subgroups during different phases of disease, and defines the priorities for research in this area. Terminology was discussed by way of a three-stage structured process: A provisional list of descriptors for each of the possible phases preceding the diagnosis of RA were circulated to members of the study group for review and feedback. Anonymised comments from the members on this list were fed back to participants before a 2-day meeting. 18 participants met to discuss these data, agree terminologies and prioritise important research questions. The study group recommended that, in prospective studies, individuals without RA are described as having: genetic risk factors for RA; environmental risk factors for RA; systemic autoimmunity associated with RA; symptoms without clinical arthritis; unclassified arthritis; which may be used in a combinatorial manner. It was recommended that the prefix 'pre-RA with:' could be used before any/any combination of the five points above but only to describe retrospectively a phase that an individual had progressed through once it was known that they have developed RA. An approach to dating disease onset was recommended. In addition, important areas for research were proposed, including research of other tissues in which an adaptive immune response may be initiated, and the identification of additional risk factors and biomarkers for the development of RA, its progression and the development of extra-articular features. These recommendations provide guidance on approaches to describe phases before the development of RA that will facilitate communication between researchers and comparisons between studies. A number of research questions have been defined, requiring new cohorts to be established and new techniques to be developed to image and collect material from different sites.
Keywords		Arthritis, Rheumatoid/diagnosis/physiopathology — Biomedical Research — Humans — Practice Guidelines as Topic — Terminology as Topic
Identifiers		DOI: 10.1136/annrheumdis-2011-200990 PMID: 22387728
Full text		Article (Published version) (111 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Mécanisme de l'inflammation articulaire (44)
Citation (ISO format)		GERLAG, Danielle M et al. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. In: Annals of the Rheumatic Diseases, 2012, vol. 71, n° 5, p. 638-41. doi: 10.1136/annrheumdis-2011-200990 https://archive-ouverte.unige.ch/unige:32489