Contribution of interferon-γ release assays (IGRAs) to the diagnosis of latent tuberculosis infection after renal transplantation

Hadaya, Karine; Bridevaux, Pierre-Olivier; Roux-Lombard, Pascale; Delort, Armelle; Saudan, Patrick; Martin, Pierre-Yves; Janssens, Jean-Paul

doi:10.1097/TP.0b013e3182907073

Scientific article

English

Contribution of interferon-γ release assays (IGRAs) to the diagnosis of latent tuberculosis infection after renal transplantation

ContributorsHadaya, Karine; Bridevaux, Pierre-Olivier; Roux-Lombard, Pascale; Delort, Armelle; Saudan, Patrick; Martin, Pierre-Yves; Janssens, Jean-Paul

Published inTransplantation, vol. 95, no. 12, p. 1485-1490

Publication date2013

Abstract

Renal transplant recipients (RTRs), as all immunosuppressed patients, are at increased risk of reactivating latent tuberculosis infection (LTBI). Detecting LTBI in this population is therefore important to prevent active TB. The tuberculin skin test (TST) has a poor sensitivity in this setting.

Keywords

Adult
Aged
Female
Humans
Immunosuppressive Agents/adverse effects/therapeutic use
Interferon-gamma/blood
Interferon-gamma Release Tests/methods
Kidney Failure, Chronic/complications/surgery
Kidney Transplantation/adverse effects
Latent Tuberculosis/blood/diagnosis
Male
Middle Aged
Models, Statistical
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Tuberculin Test/methods

Affiliation

Research group

Citation (ISO format)

HADAYA, Karine et al. Contribution of interferon-γ release assays (IGRAs) to the diagnosis of latent tuberculosis infection after renal transplantation. In: Transplantation, 2013, vol. 95, n° 12, p. 1485–1490. doi: 10.1097/TP.0b013e3182907073

Article (Published version)

Identifiers

PID : unige:32438
DOI : 10.1097/TP.0b013e3182907073
PMID : 23694948

ISSN of the journal0041-1337

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Contribution of interferon-γ release assays (IGRAs) to the diagnosis of latent tuberculosis infection after renal transplantation

Renal transplant recipients (RTRs), as all immunosuppressed patients, are at increased risk of reactivating latent tuberculosis infection (LTBI). Detecting LTBI in this population is therefore important to prevent active TB. The tuberculin skin test (TST) has a poor sensitivity in this setting.

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