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Scientific article
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Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1

Published inPloS one, vol. 4, no. 11, e7904
Publication date2009
Abstract

A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas, a malignant soft tissue tumor widely believed to originate from as yet unidentified pluripotent stem cells. The resulting fusion protein has no DNA binding motifs but possesses protein-protein interaction domains that are believed to mediate association with chromatin remodeling complexes. Despite recent advances in the identification of molecules that interact with SYT-SSX and with the corresponding wild type SYT and SSX proteins, the mechanisms whereby the SYT-SSX might contribute to neoplastic transformation remain unclear. Epigenetic deregulation has been suggested to be one possible mechanism.

Keywords
  • Adolescent
  • Alleles
  • Child
  • Chromatin/metabolism
  • CpG Islands
  • DNA/genetics
  • Epigenesis, Genetic
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Humans
  • Mesenchymal Stromal Cells/cytology
  • Oncogene Proteins, Fusion/genetics/physiology
  • Sarcoma, Synovial/metabolism
  • Transcription, Genetic
  • Translocation, Genetic
Citation (ISO format)
CIRONI, Luisa et al. Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1. In: PloS one, 2009, vol. 4, n° 11, p. e7904. doi: 10.1371/journal.pone.0007904
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Article (Published version)
Identifiers
ISSN of the journal1932-6203
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