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Title

Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1

Authors
Cironi, Luisa
Provero, Paolo
Riggi, Nicola
Janiszewska, Michalina
Suva, Mario-Luca
Kindler, Vincent
Stamenkovic, Ivan
Published in PLOS ONE. 2009, vol. 4, no. 11, p. e7904
Abstract A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas, a malignant soft tissue tumor widely believed to originate from as yet unidentified pluripotent stem cells. The resulting fusion protein has no DNA binding motifs but possesses protein-protein interaction domains that are believed to mediate association with chromatin remodeling complexes. Despite recent advances in the identification of molecules that interact with SYT-SSX and with the corresponding wild type SYT and SSX proteins, the mechanisms whereby the SYT-SSX might contribute to neoplastic transformation remain unclear. Epigenetic deregulation has been suggested to be one possible mechanism.
Keywords AdolescentAllelesChildChromatin/metabolismCpG IslandsDNA/geneticsEpigenesis, GeneticGene Expression ProfilingGene Expression RegulationHumansMesenchymal Stromal Cells/cytologyOncogene Proteins, Fusion/genetics/physiologySarcoma, Synovial/metabolismTranscription, GeneticTranslocation, Genetic
Identifiers
PMID: 19936258
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Article (Published version) (1.2 MB) - public document Free access
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Research group Chirurgie orthopédique et traumatologique (98)
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CIRONI, Luisa et al. Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1. In: PLOS ONE, 2009, vol. 4, n° 11, p. e7904. https://archive-ouverte.unige.ch/unige:32429

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Deposited on : 2013-12-18

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