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Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1 |
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Published in | PloS one. 2009, vol. 4, no. 11, e7904 | |
Abstract | A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas, a malignant soft tissue tumor widely believed to originate from as yet unidentified pluripotent stem cells. The resulting fusion protein has no DNA binding motifs but possesses protein-protein interaction domains that are believed to mediate association with chromatin remodeling complexes. Despite recent advances in the identification of molecules that interact with SYT-SSX and with the corresponding wild type SYT and SSX proteins, the mechanisms whereby the SYT-SSX might contribute to neoplastic transformation remain unclear. Epigenetic deregulation has been suggested to be one possible mechanism. | |
Keywords | Adolescent — Alleles — Child — Chromatin/metabolism — CpG Islands — DNA/genetics — Epigenesis, Genetic — Gene Expression Profiling — Gene Expression Regulation — Humans — Mesenchymal Stromal Cells/cytology — Oncogene Proteins, Fusion/genetics/physiology — Sarcoma, Synovial/metabolism — Transcription, Genetic — Translocation, Genetic | |
Identifiers | PMID: 19936258 | |
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Research group | Chirurgie orthopédique et traumatologique (98) | |
Citation (ISO format) | CIRONI, Luisa et al. Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1. In: PloS one, 2009, vol. 4, n° 11, p. e7904. doi: 10.1371/journal.pone.0007904 https://archive-ouverte.unige.ch/unige:32429 |