Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1

Cironi, Luisa; Provero, Paolo; Riggi, Nicola; Janiszewska, Michalina; Suva, Domizio; Suva, Mario-Luca; Kindler, Vincent; Stamenkovic, Ivan

doi:10.1371/journal.pone.0007904

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Title		Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1
Authors		Cironi, Luisa Provero, Paolo Riggi, Nicola Janiszewska, Michalina Suva, Domizio Suva, Mario-Luca Kindler, Vincent Stamenkovic, Ivan
Published in		PLOS ONE. 2009, vol. 4, no. 11, p. e7904
Abstract		A characteristic SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is detectable in almost all synovial sarcomas, a malignant soft tissue tumor widely believed to originate from as yet unidentified pluripotent stem cells. The resulting fusion protein has no DNA binding motifs but possesses protein-protein interaction domains that are believed to mediate association with chromatin remodeling complexes. Despite recent advances in the identification of molecules that interact with SYT-SSX and with the corresponding wild type SYT and SSX proteins, the mechanisms whereby the SYT-SSX might contribute to neoplastic transformation remain unclear. Epigenetic deregulation has been suggested to be one possible mechanism.
Keywords		Adolescent — Alleles — Child — Chromatin/metabolism — CpG Islands — DNA/genetics — Epigenesis, Genetic — Gene Expression Profiling — Gene Expression Regulation — Humans — Mesenchymal Stromal Cells/cytology — Oncogene Proteins, Fusion/genetics/physiology — Sarcoma, Synovial/metabolism — Transcription, Genetic — Translocation, Genetic
Identifiers		DOI: 10.1371/journal.pone.0007904 PMID: 19936258
Full text		Article (Published version) (1.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group		Chirurgie orthopédique et traumatologique (98)
Citation (ISO format)		CIRONI, Luisa et al. Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1. In: PLOS ONE, 2009, vol. 4, n° 11, p. e7904. doi: 10.1371/journal.pone.0007904 https://archive-ouverte.unige.ch/unige:32429

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Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1