With the evolution of the development of knowledge and progress in automatic technologies, the human society gradually turned into a sedentary population. It is moreover clearly established that the physical activity is insufficient in Europe and in the developed countries. The physical activity is certainly beneficial for many reasons, but it is especially the inactivity which is dangerous. To date, many scientific publications showed the benefits of the physical activity as well in the treatment of chronic diseases as in the prevention of those diseases. The objective of this article is, on the one hand, to show the concrete influence of the physical activity as a treatment, and on the other hand to briefly review its impact on different systems of the human organism.