IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

Vigne, Solenne; Palmer-Lourenco, Gaby; Martin, Praxedis Sina; Lamacchia, Céline; Strebel, Deborah; Rodriguez, Emiliana; Olleros, Maria-Luisa; Vesin, Marie-Dominique; Garcia, Irène; Ronchi, Francesca; Sallusto, Federica; Sims, John E; Gabay, Cem

doi:10.1182/blood-2012-06-439026

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Title		IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells
Authors		Vigne, Solenne Palmer-Lourenco, Gaby Martin, Praxedis Sina Lamacchia, Céline Strebel, Deborah Rodriguez, Emiliana Olleros, Maria-Luisa Vesin, Marie-Dominique Garcia, Irène Ronchi, Francesca Sallusto, Federica Sims, John E Gabay, Cem show all authors [1 - 13]
Published in		Blood. 2012, vol. 120, no. 17, p. 3478-87
Abstract		The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune cells. Here we show that, among T cells, the IL-36 receptor is predominantly expressed on naive CD4(+) T cells and that IL-36 cytokines act directly on naive T cells by enhancing both cell proliferation and IL-2 secretion. IL-36β acts in synergy with IL-12 to promote Th1 polarization and IL-36 signaling is also involved in mediating Th1 immune responses to Bacillus Calmette-Guerin infection in vivo. Our findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo.
Keywords		Adaptive Immunity — Animals — Cell Differentiation — Cell Proliferation — Interleukin-1/immunology/pharmacology — Interleukin-12/immunology/pharmacology — Interleukin-2/biosynthesis/immunology — Lymphocyte Activation — Mice — Mice, Knockout — Mycobacterium bovis/immunology — Primary Cell Culture — Receptors, Interleukin-1/deficiency/genetics/immunology — Signal Transduction/genetics/immunology — Th1 Cells/cytology/immunology/microbiology — Tuberculosis/genetics/immunology/metabolism/veterinary
Identifiers		DOI: 10.1182/blood-2012-06-439026 PMID: 22968459
Full text		Article (Published version) (1.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Mécanisme de l'inflammation articulaire (44) Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)
Project		Swiss National Science Foundation: 3200A0-118196
Citation (ISO format)		VIGNE, Solenne et al. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. In: Blood, 2012, vol. 120, n° 17, p. 3478-87. doi: 10.1182/blood-2012-06-439026 https://archive-ouverte.unige.ch/unige:32289