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IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

Martin, Praxedis Sina
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Published in Blood. 2012, vol. 120, no. 17, p. 3478-87
Abstract The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune cells. Here we show that, among T cells, the IL-36 receptor is predominantly expressed on naive CD4(+) T cells and that IL-36 cytokines act directly on naive T cells by enhancing both cell proliferation and IL-2 secretion. IL-36β acts in synergy with IL-12 to promote Th1 polarization and IL-36 signaling is also involved in mediating Th1 immune responses to Bacillus Calmette-Guerin infection in vivo. Our findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo.
Keywords Adaptive ImmunityAnimalsCell DifferentiationCell ProliferationInterleukin-1/immunology/pharmacologyInterleukin-12/immunology/pharmacologyInterleukin-2/biosynthesis/immunologyLymphocyte ActivationMiceMice, KnockoutMycobacterium bovis/immunologyPrimary Cell CultureReceptors, Interleukin-1/deficiency/genetics/immunologySignal Transduction/genetics/immunologyTh1 Cells/cytology/immunology/microbiologyTuberculosis/genetics/immunology/metabolism/veterinary
PMID: 22968459
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Article (Published version) (1.2 MB) - public document Free access
Research groups Mécanisme de l'inflammation articulaire (44)
Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500)
Swiss National Science Foundation: 3200A0-118196
(ISO format)
VIGNE, Solenne et al. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. In: Blood, 2012, vol. 120, n° 17, p. 3478-87. doi: 10.1182/blood-2012-06-439026 https://archive-ouverte.unige.ch/unige:32289

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Deposited on : 2013-12-17

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