IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells

Vigne, Solenne; Palmer-Lourenco, Gaby; Martin, Praxedis Sina; Lamacchia, Céline; Strebel, Deborah; Rodriguez, Emiliana; Olleros, Maria-Luisa; Vesin, Marie-Dominique; Garcia, Irène; Ronchi, Francesca; Sallusto, Federica; Sims, John E; Gabay, Cem

doi:10.1182/blood-2012-06-439026

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Title		IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells
Authors		Vigne, Solenne Palmer-Lourenco, Gaby Martin, Praxedis Sina Lamacchia, Céline Strebel, Deborah Rodriguez, Emiliana Olleros, Maria-Luisa Vesin, Marie-Dominique Garcia, Irène Ronchi, Francesca Sallusto, Federica Sims, John E Gabay, Cem show all authors [1 - 13]
Published in		Blood. 2012, vol. 120, no. 17, p. 3478-87
Abstract		The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune cells. Here we show that, among T cells, the IL-36 receptor is predominantly expressed on naive CD4(+) T cells and that IL-36 cytokines act directly on naive T cells by enhancing both cell proliferation and IL-2 secretion. IL-36β acts in synergy with IL-12 to promote Th1 polarization and IL-36 signaling is also involved in mediating Th1 immune responses to Bacillus Calmette-Guerin infection in vivo. Our findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo.
Keywords		Adaptive Immunity — Animals — Cell Differentiation — Cell Proliferation — Interleukin-1/immunology/pharmacology — Interleukin-12/immunology/pharmacology — Interleukin-2/biosynthesis/immunology — Lymphocyte Activation — Mice — Mice, Knockout — Mycobacterium bovis/immunology — Primary Cell Culture — Receptors, Interleukin-1/deficiency/genetics/immunology — Signal Transduction/genetics/immunology — Th1 Cells/cytology/immunology/microbiology — Tuberculosis/genetics/immunology/metabolism/veterinary
Identifiers		DOI: 10.1182/blood-2012-06-439026 PMID: 22968459
Full text		Article (Published version) (1.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research groups		Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500) Mécanisme de l'inflammation articulaire (44)
Project		FNS: 3200A0-118196
Citation (ISO format)		VIGNE, Solenne et al. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. In: Blood, 2012, vol. 120, n° 17, p. 3478-87. doi: 10.1182/blood-2012-06-439026 https://archive-ouverte.unige.ch/unige:32289