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IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells |
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Published in | Blood. 2012, vol. 120, no. 17, p. 3478-87 | |
Abstract | The interleukin-1 (IL-1) superfamily of cytokines comprises a set of pivotal mediators of inflammation. Among them, the action of IL-36 cytokines in immune responses has remained elusive. In a recent study, we demonstrated a direct effect of IL-36 on immune cells. Here we show that, among T cells, the IL-36 receptor is predominantly expressed on naive CD4(+) T cells and that IL-36 cytokines act directly on naive T cells by enhancing both cell proliferation and IL-2 secretion. IL-36β acts in synergy with IL-12 to promote Th1 polarization and IL-36 signaling is also involved in mediating Th1 immune responses to Bacillus Calmette-Guerin infection in vivo. Our findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo. | |
Keywords | Adaptive Immunity — Animals — Cell Differentiation — Cell Proliferation — Interleukin-1/immunology/pharmacology — Interleukin-12/immunology/pharmacology — Interleukin-2/biosynthesis/immunology — Lymphocyte Activation — Mice — Mice, Knockout — Mycobacterium bovis/immunology — Primary Cell Culture — Receptors, Interleukin-1/deficiency/genetics/immunology — Signal Transduction/genetics/immunology — Th1 Cells/cytology/immunology/microbiology — Tuberculosis/genetics/immunology/metabolism/veterinary | |
Identifiers | PMID: 22968459 | |
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Research groups | Mécanisme de l'inflammation articulaire (44) Rôles des cytokines de la famille du TNF dans les infections mycobactériennes (500) | |
Project | Swiss National Science Foundation: 3200A0-118196 | |
Citation (ISO format) | VIGNE, Solenne et al. IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. In: Blood, 2012, vol. 120, n° 17, p. 3478-87. doi: 10.1182/blood-2012-06-439026 https://archive-ouverte.unige.ch/unige:32289 |