Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

Tansey, Katherine E; Guipponi, Michel; Perroud, Nader Ali; Bondolfi, Guido; Domenici, Enrico; Evans, David; Hall, Stephanie K; Hauser, Joanna; Henigsberg, Neven; Hu, Xiaolan; Jerman, Borut; Maier, Wolfgang; Mors, Ole; O'Donovan, Michael; Peters, Tim J; Placentino, Anna; Rietschel, Marcella; Souery, Daniel; Aitchison, Katherine J; Craig, Ian; Farmer, Anne; Wendland, Jens R; Malafosse, Alain; Holmans, Peter; Lewis, Glyn; Lewis, Cathryn M; Stensbøl, Tine Bryan; Kapur, Shitij; McGuffin, Peter; Uher, Rudolf

doi:10.1371/journal.pmed.1001326

Article scientifique

Accès libre

Anglais

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

Publié dansPLoS medicine, vol. 9, no. 10, e1001326

Date de publication2012

Résumé

It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way.

Mots-clés

Antidepressive Agents/therapeutic use
Depressive Disorder, Major/drug therapy/genetics
Female
Genome-Wide Association Study
Genotype
Humans
Linear Models
Male
Polymorphism, Genetic/genetics
Serotonin Uptake Inhibitors/therapeutic use
Treatment Outcome

Structure d'affiliation

Groupe de recherche

Médecine psychosomatique, neurosciences cliniques et mindfulness (690)

Citation (format ISO)

TANSEY, Katherine E et al. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. In: PLoS medicine, 2012, vol. 9, n° 10, p. e1001326. doi: 10.1371/journal.pmed.1001326

Article (Published version)

Identifiants

PID : unige:32274
DOI : 10.1371/journal.pmed.1001326
PMID : 23091423

ISSN du journal1549-1277

614vues

436téléchargements

Création12.12.2013 16:58:00

Première validation12.12.2013 16:58:00

Heure de mise à jour14.03.2023 20:44:17

Changement de statut14.03.2023 20:44:16

Dernière indexation16.01.2024 08:33:28

Archive ouverte UNIGE

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

Informations techniques