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Scientific article
Open access
English

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

Published inPLoS medicine, vol. 9, no. 10, e1001326
Publication date2012
Abstract

It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way.

Keywords
  • Antidepressive Agents/therapeutic use
  • Depressive Disorder, Major/drug therapy/genetics
  • Female
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Linear Models
  • Male
  • Polymorphism, Genetic/genetics
  • Serotonin Uptake Inhibitors/therapeutic use
  • Treatment Outcome
Citation (ISO format)
TANSEY, Katherine E et al. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. In: PLoS medicine, 2012, vol. 9, n° 10, p. e1001326. doi: 10.1371/journal.pmed.1001326
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1549-1277
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