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Title

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

Authors
Tansey, Katherine E
Domenici, Enrico
Evans, David
Hall, Stephanie K
Hauser, Joanna
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Published in PLOS Medicine. 2012, vol. 9, no. 10, p. e1001326
Abstract It has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way.
Keywords Antidepressive Agents/therapeutic useDepressive Disorder, Major/drug therapy/geneticsFemaleGenome-Wide Association StudyGenotypeHumansLinear ModelsMalePolymorphism, Genetic/geneticsSerotonin Uptake Inhibitors/therapeutic useTreatment Outcome
Identifiers
PMID: 23091423
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Article (Published version) (443 Kb) - public document Free access
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Research group Evaluation et traitement de la dépression (690)
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TANSEY, Katherine E et al. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. In: PLOS Medicine, 2012, vol. 9, n° 10, p. e1001326. https://archive-ouverte.unige.ch/unige:32274

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Deposited on : 2013-12-17

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