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Scientific article
Open access
English

Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome

Published inCirculation. Cardiovascular genetics, vol. 5, no. 4, p. 430-440
Publication date2012
Abstract

Essential hypertension, a common complex disease, displays substantial genetic influence. Contemporary methods to dissect the genetic basis of complex diseases such as the genomewide association study are powerful, yet a large gap exists between the fraction of population trait variance explained by such associations and total disease heritability.

Keywords
  • Adrenal Glands/metabolism
  • Animals
  • Base Sequence
  • Blood Pressure/genetics
  • Computational Biology/methods
  • Enhancer Elements, Genetic/genetics
  • Genetic Predisposition to Disease
  • Humans
  • Hypertension/genetics
  • Luciferases/metabolism
  • Male
  • Meta-Analysis as Topic
  • Metabolic Syndrome X/genetics
  • Mice
  • Molecular Sequence Data
  • Myocardium/metabolism/pathology
  • Neurosecretory Systems/metabolism
  • Nucleotide Motifs/genetics
  • Oligonucleotide Array Sequence Analysis
  • Promoter Regions, Genetic/genetics
  • Protein Binding/genetics
  • RNA, Messenger/genetics/metabolism
  • Transcription Factors/metabolism
  • Transcription, Genetic
  • Transcriptional Activation/genetics
  • Transcriptome/genetics
Citation (ISO format)
FRIESE, Ryan S et al. Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome. In: Circulation. Cardiovascular genetics, 2012, vol. 5, n° 4, p. 430–440. doi: 10.1161/CIRCGENETICS.111.962415
Main files (1)
Article (Accepted version)
accessLevelPublic
Identifiers
ISSN of the journal1942-3268
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432downloads

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