Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome

Friese, Ryan S; Ye, Chun; Nievergelt, Caroline M; Schork, Andrew J; Mahapatra, Nitish R; Rao, Fangwen; Napolitan, Philip S; Waalen, Jill; Ehret, Georg Benedikt; Munroe, Patricia B; Schmid-Schönbein, Geert W; Eskin, Eleazar; O'Connor, Daniel T

doi:10.1161/CIRCGENETICS.111.962415

Scientific article

Open access

English

Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome

ContributorsFriese, Ryan S; Ye, Chun; Nievergelt, Caroline M; Schork, Andrew J; Mahapatra, Nitish R; Rao, Fangwen; Napolitan, Philip S; Waalen, Jill; Ehret, Georg Benedikt; Munroe, Patricia B; Schmid-Schönbein, Geert W; Eskin, Eleazar; O'Connor, Daniel T

Published inCirculation. Cardiovascular genetics, vol. 5, no. 4, p. 430-440

Publication date2012

Abstract

Essential hypertension, a common complex disease, displays substantial genetic influence. Contemporary methods to dissect the genetic basis of complex diseases such as the genomewide association study are powerful, yet a large gap exists between the fraction of population trait variance explained by such associations and total disease heritability.

Keywords

Adrenal Glands/metabolism
Animals
Base Sequence
Blood Pressure/genetics
Computational Biology/methods
Enhancer Elements, Genetic/genetics
Genetic Predisposition to Disease
Humans
Hypertension/genetics
Luciferases/metabolism
Male
Meta-Analysis as Topic
Metabolic Syndrome X/genetics
Mice
Molecular Sequence Data
Myocardium/metabolism/pathology
Neurosecretory Systems/metabolism
Nucleotide Motifs/genetics
Oligonucleotide Array Sequence Analysis
Promoter Regions, Genetic/genetics
Protein Binding/genetics
RNA, Messenger/genetics/metabolism
Transcription Factors/metabolism
Transcription, Genetic
Transcriptional Activation/genetics
Transcriptome/genetics

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Research group

Traits génétiques complexes (901)

Citation (ISO format)

FRIESE, Ryan S et al. Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome. In: Circulation. Cardiovascular genetics, 2012, vol. 5, n° 4, p. 430–440. doi: 10.1161/CIRCGENETICS.111.962415

Article (Accepted version)

Identifiers

PID : unige:32238
DOI : 10.1161/CIRCGENETICS.111.962415
PMID : 22670052

ISSN of the journal1942-3268

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Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome

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