Scientific article

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Published inMagnetic resonance in medicine, vol. 68, no. 5, p. 1544-1552
Publication date2012

The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss measurements of iron oxide nanoparticle containing tissues saturate at medium concentrations and show a nonlinear/nonproportional intensity to concentration profile due to the competing effects of T₁ and T₂ relaxation. A concentration calibration phantom and an in vivo study of intra-articular injection in a rat knee of known concentrations of iron oxide were assessed using the difference-ultrashort echo time sequence giving a positive, quantifiable, unambiguous iron signal and monotonic, increasing concentration response over a wide concentration range in the phantom with limited susceptibility artifacts and high contrast in vivo to all other tissues. This improved dynamic response to concentration opens possibilities for quantification due to its linear nature at physiologically relevant concentrations.

  • Algorithms
  • Animals
  • Contrast Media/administration & dosage
  • Dextrans/administration & dosage/diagnostic use
  • Female
  • Image Enhancement/methods
  • Image Interpretation, Computer-Assisted/methods
  • Injections, Intra-Arterial
  • Joints/anatomy & histology
  • Magnetic Resonance Imaging/methods
  • Magnetite Nanoparticles/administration & dosage/diagnostic use
  • Rats
  • Rats, Inbred Lew
  • Reproducibility of Results
  • Sensitivity and Specificity
Citation (ISO format)
CROWE, Lindsey et al. Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles. In: Magnetic resonance in medicine, 2012, vol. 68, n° 5, p. 1544–1552. doi: 10.1002/mrm.24166
Main files (1)
Article (Published version)
ISSN of the journal0740-3194

Technical informations

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