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Title

Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles

Authors
Salaklang, J
Redjem, A
Petri-Fink, A
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Published in Magnetic Resonance in Medicine. 2012, vol. 68, no. 5, p. 1544-52
Abstract The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss measurements of iron oxide nanoparticle containing tissues saturate at medium concentrations and show a nonlinear/nonproportional intensity to concentration profile due to the competing effects of T₁ and T₂ relaxation. A concentration calibration phantom and an in vivo study of intra-articular injection in a rat knee of known concentrations of iron oxide were assessed using the difference-ultrashort echo time sequence giving a positive, quantifiable, unambiguous iron signal and monotonic, increasing concentration response over a wide concentration range in the phantom with limited susceptibility artifacts and high contrast in vivo to all other tissues. This improved dynamic response to concentration opens possibilities for quantification due to its linear nature at physiologically relevant concentrations.
Keywords AlgorithmsAnimalsContrast Media/administration & dosageDextrans/administration & dosage/diagnostic useFemaleImage Enhancement/methodsImage Interpretation, Computer-Assisted/methodsInjections, Intra-ArterialJoints/anatomy & histologyMagnetic Resonance Imaging/methodsMagnetite Nanoparticles/administration & dosage/diagnostic useRatsRats, Inbred LewReproducibility of ResultsSensitivity and Specificity
Identifiers
PMID: 22294467
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Research group Imagerie cardiaque fonctionnelle (541)
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CROWE, Lindsey et al. Improved dynamic response assessment for intra-articular injected iron oxide nanoparticles. In: Magnetic Resonance in Medicine, 2012, vol. 68, n° 5, p. 1544-52. https://archive-ouverte.unige.ch/unige:32090

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Deposited on : 2013-12-13

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