Intensity modulated proton and photon therapy for early prostate cancer with or without transperineal injection of a polyethylen glycol spacer: a treatment planning comparison study

Weber, Damien; Zilli, Thomas; Vallée, Jean-Paul; Rouzaud, Michel; Miralbell, Raymond; Cozzi, Luca

doi:10.1016/j.ijrobp.2012.03.028

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Title		Intensity modulated proton and photon therapy for early prostate cancer with or without transperineal injection of a polyethylen glycol spacer: a treatment planning comparison study
Authors		Weber, Damien Zilli, Thomas Vallée, Jean-Paul Rouzaud, Michel Miralbell, Raymond Cozzi, Luca
Published in		International Journal of Radiation Oncology, Biology, Physics. 2012, vol. 84, no. 3, p. e311-8
Abstract		Rectal toxicity is a serious adverse effect in early-stage prostate cancer patients treated with curative radiation therapy (RT). Injecting a spacer between Denonvilliers' fascia increases the distance between the prostate and the anterior rectal wall and may thus decrease the rectal radiation-induced toxicity. We assessed the dosimetric impact of this spacer with advanced delivery RT techniques, including intensity modulated RT (IMRT), volumetric modulated arc therapy (VMAT), and intensity modulated proton beam RT (IMPT).
Keywords		Absorbable Implants — Aged — Humans — Male — Middle Aged — Photons/therapeutic use — Polyethylene Glycols/administration & dosage — Prostate/radiography — Prostatic Neoplasms/pathology/radiography/radiotherapy — Protons/therapeutic use — Radiation Injuries/prevention & control — Radiotherapy Dosage — Radiotherapy Planning, Computer-Assisted/methods — Radiotherapy, Intensity-Modulated/methods — Rectum/radiation effects/radiography — Urinary Bladder/radiation effects/radiography
Identifiers		DOI: 10.1016/j.ijrobp.2012.03.028 PMID: 22999271
Full text		Article (Published version) (715 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Groupe Mirabell Raymond (radio-oncologie) (685) Imagerie cardiaque fonctionnelle (541)
Citation (ISO format)		WEBER, Damien et al. Intensity modulated proton and photon therapy for early prostate cancer with or without transperineal injection of a polyethylen glycol spacer: a treatment planning comparison study. In: International Journal of Radiation Oncology, Biology, Physics, 2012, vol. 84, n° 3, p. e311-8. doi: 10.1016/j.ijrobp.2012.03.028 https://archive-ouverte.unige.ch/unige:32078