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Title

Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial

Authors
Brunner-Ferber, Françoise
François, Bruno
Carlet, Jean
Published in Intensive Care Medicine. 2012, vol. 38, no. 7, p. 1118-25
Abstract Anti-virulence strategies have not been evaluated for the prevention of bacterial infections. Prolonged colonization of intubated patients with Pseudomonas aeruginosa isolates producing high-levels of the quorum sensing (QS)-regulated virulence factor rhamnolipids has been associated with ventilator-associated pneumonia (VAP). In this pathogen, azithromycin reduces QS-regulated virulence. We aimed to assess whether azithromycin could prevent VAP in patients colonized by rhamnolipids producing isolates.
Keywords Anti-Bacterial Agents/therapeutic useAntibiotic ProphylaxisAzithromycin/pharmacology/therapeutic useDouble-Blind MethodFemaleGlycolipids/pharmacology/therapeutic useHumansMaleMiddle AgedPilot ProjectsPneumonia, Ventilator-Associated/drug therapy/microbiology/prevention & controlPseudomonas Infections/drug therapy/microbiology/prevention & controlPseudomonas aeruginosa/drug effects/pathogenicityQuorum Sensing/drug effectsVirulence/drug effects
Identifiers
PMID: 22527075
Full text
Article (Published version) (233 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Quorom-sensing et gènes de virulence (301)
Projects FNS: 4049-063239
FNS: 320000-108106
Citation
(ISO format)
VAN DELDEN, Christian et al. Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial. In: Intensive Care Medicine, 2012, vol. 38, n° 7, p. 1118-25. https://archive-ouverte.unige.ch/unige:32040

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Deposited on : 2013-12-11

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