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Scientific article
Open access
English

Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial

Published inIntensive care medicine, vol. 38, no. 7, p. 1118-1125
Collection
  • Open Access - Licence nationale Springer
Publication date2012
Abstract

Anti-virulence strategies have not been evaluated for the prevention of bacterial infections. Prolonged colonization of intubated patients with Pseudomonas aeruginosa isolates producing high-levels of the quorum sensing (QS)-regulated virulence factor rhamnolipids has been associated with ventilator-associated pneumonia (VAP). In this pathogen, azithromycin reduces QS-regulated virulence. We aimed to assess whether azithromycin could prevent VAP in patients colonized by rhamnolipids producing isolates.

Keywords
  • Anti-Bacterial Agents/therapeutic use
  • Antibiotic Prophylaxis
  • Azithromycin/pharmacology/therapeutic use
  • Double-Blind Method
  • Female
  • Glycolipids/pharmacology/therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Pneumonia, Ventilator-Associated/drug therapy/microbiology/prevention & control
  • Pseudomonas Infections/drug therapy/microbiology/prevention & control
  • Pseudomonas aeruginosa/drug effects/pathogenicity
  • Quorum Sensing/drug effects
  • Virulence/drug effects
Funding
  • Swiss National Science Foundation - Novel appproaches to detect and circumvent antibiotic resistance in Pseudomonas aeruginosa
  • Swiss National Science Foundation - 320000-108106
Citation (ISO format)
VAN DELDEN, Christian et al. Azithromycin to prevent Pseudomonas aeruginosa ventilator-associated pneumonia by inhibition of quorum sensing: a randomized controlled trial. In: Intensive care medicine, 2012, vol. 38, n° 7, p. 1118–1125. doi: 10.1007/s00134-012-2559-3
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0342-4642
674views
319downloads

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