Scientific article

Multi-targeted screening of botanicals in food supplements by liquid chromatography with tandem mass spectrometry

Published inFood chemistry, vol. 138, no. 1, p. 709-717
Publication date2013

Safety, quality and composition assessments of food supplements based on botanical ingredients are of major concern, as they have usually not been through a rigorous testing process as required for the approval of therapeutic phytopreparations. Therefore, an efficient multi-targeted method was developed to screen selected botanicals of interest in herbal food supplements. Liquid chromatography coupled with a hybrid triple quadrupole linear ion trap was used for this purpose. Botanicals were characterised by means of appropriate biomarkers, which were unambiguously identified by mass spectrometry using an information dependent acquisition experiment which combined a multiple reaction monitoring survey with dependent enhanced product ion scans. During this procedure, product ion scans of targeted analytes were generated at three collision energies and compared with an in-house library of MS/MS spectra acquired from reference standards of all biomarkers. This generic method enables detection, identification and quantification of 98 biomarkers intended to characterise 79 selected plants.

  • Herbal food supplements
  • Botanicals
  • Targeted screening
  • Food safety
  • Authenticity
  • Quality control
Citation (ISO format)
MATHON, Caroline et al. Multi-targeted screening of botanicals in food supplements by liquid chromatography with tandem mass spectrometry. In: Food chemistry, 2013, vol. 138, n° 1, p. 709–717. doi: 10.1016/j.foodchem.2012.10.091
Main files (1)
Article (Published version)
ISSN of the journal0308-8146

Technical informations

Creation12/11/2013 10:42:00 AM
First validation12/11/2013 10:42:00 AM
Update time03/14/2023 8:42:32 PM
Status update03/14/2023 8:42:32 PM
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