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Intravenous buspirone for the prevention of postoperative nausea and vomiting

Kranke, Peter
Röhm, Kerstin D
Diemunsch, Pierre
Gan, Tong J
Apfel, Christian C
Eberhart, Leopold
Minkowitz, Harold S
Wallenborn, Jan
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Published in European Journal of Clinical Pharmacology. 2012, vol. 68, no. 11, p. 1465-72
Abstract Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (PONV) is unknown.
Keywords AdultAgedAged, 80 and overAnti-Anxiety Agents/administration & dosage/adverse effects/pharmacokinetics/therapeutic useAntiemetics/administration & dosage/adverse effects/pharmacokinetics/therapeutic useBuspirone/administration & dosage/adverse effects/analogs & derivatives/blood/pharmacokinetics/therapeutic useDopamine Antagonists/administration & dosage/adverse effects/pharmacokinetics/therapeutic useDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansIncidenceInjections, IntravenousMaleMiddle AgedPostoperative Nausea and Vomiting/blood/epidemiology/prevention & controlReceptor, Serotonin, 5-HT1A/chemistry/metabolismReceptors, Dopamine D2/antagonists & inhibitors/metabolismReceptors, Dopamine D3/antagonists & inhibitors/metabolismSerotonin 5-HT1 Receptor Agonists/administration & dosage/adverse effects/therapeutic useYoung Adult
PMID: 22546895
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Research group La Médecine Périopératoire et l'anesthésie (70)
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KRANKE, Peter et al. Intravenous buspirone for the prevention of postoperative nausea and vomiting. In: European Journal of Clinical Pharmacology, 2012, vol. 68, n° 11, p. 1465-72. https://archive-ouverte.unige.ch/unige:31969

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Deposited on : 2013-12-10

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