Professional article
Open access

Intravenous buspirone for the prevention of postoperative nausea and vomiting

Published inEuropean journal of clinical pharmacology, vol. 68, no. 11, p. 1465-1472
  • Open Access - Licence nationale Springer
Publication date2012

Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (PONV) is unknown.

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Anxiety Agents/administration & dosage/adverse effects/pharmacokinetics/therapeutic use
  • Antiemetics/administration & dosage/adverse effects/pharmacokinetics/therapeutic use
  • Buspirone/administration & dosage/adverse effects/analogs & derivatives/blood/pharmacokinetics/therapeutic use
  • Dopamine Antagonists/administration & dosage/adverse effects/pharmacokinetics/therapeutic use
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Incidence
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Postoperative Nausea and Vomiting/blood/epidemiology/prevention & control
  • Receptor, Serotonin, 5-HT1A/chemistry/metabolism
  • Receptors, Dopamine D2/antagonists & inhibitors/metabolism
  • Receptors, Dopamine D3/antagonists & inhibitors/metabolism
  • Serotonin 5-HT1 Receptor Agonists/administration & dosage/adverse effects/therapeutic use
  • Young Adult
Citation (ISO format)
KRANKE, Peter et al. Intravenous buspirone for the prevention of postoperative nausea and vomiting. In: European journal of clinical pharmacology, 2012, vol. 68, n° 11, p. 1465–1472. doi: 10.1007/s00228-012-1284-8
Main files (1)
Article (Published version)
ISSN of the journal0031-6970

Technical informations

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First validation10/28/2013 4:23:00 PM
Update time03/14/2023 8:42:08 PM
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