Intravenous buspirone for the prevention of postoperative nausea and vomiting

Kranke, Peter; Röhm, Kerstin D; Diemunsch, Pierre; Gan, Tong J; Apfel, Christian C; Eberhart, Leopold; Minkowitz, Harold S; Wallenborn, Jan; Chassard, Dominique; Lebuffe, Gilles; Fox, Gabriel M; Tramer, Martin

doi:10.1007/s00228-012-1284-8

Professional article

English

Intravenous buspirone for the prevention of postoperative nausea and vomiting

ContributorsKranke, Peter; Röhm, Kerstin D; Diemunsch, Pierre; Gan, Tong J; Apfel, Christian C; Eberhart, Leopold; Minkowitz, Harold S; Wallenborn, Jan; Chassard, Dominique; Lebuffe, Gilles; Fox, Gabriel M; Tramer, Martin

Published inEuropean journal of clinical pharmacology, vol. 68, no. 11, p. 1465-1472

Collection

Open Access - Licence nationale Springer

Publication date2012

Abstract

Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (PONV) is unknown.

Keywords

Adult
Aged
Aged, 80 and over
Anti-Anxiety Agents/administration & dosage/adverse effects/pharmacokinetics/therapeutic use
Antiemetics/administration & dosage/adverse effects/pharmacokinetics/therapeutic use
Buspirone/administration & dosage/adverse effects/analogs & derivatives/blood/pharmacokinetics/therapeutic use
Dopamine Antagonists/administration & dosage/adverse effects/pharmacokinetics/therapeutic use
Dose-Response Relationship, Drug
Double-Blind Method
Female
Humans
Incidence
Injections, Intravenous
Male
Middle Aged
Postoperative Nausea and Vomiting/blood/epidemiology/prevention & control
Receptor, Serotonin, 5-HT1A/chemistry/metabolism
Receptors, Dopamine D2/antagonists & inhibitors/metabolism
Receptors, Dopamine D3/antagonists & inhibitors/metabolism
Serotonin 5-HT1 Receptor Agonists/administration & dosage/adverse effects/therapeutic use
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research groups

La Médecine Périopératoire et l'anesthésie (70)

Citation (ISO format)

KRANKE, Peter et al. Intravenous buspirone for the prevention of postoperative nausea and vomiting. In: European journal of clinical pharmacology, 2012, vol. 68, n° 11, p. 1465–1472. doi: 10.1007/s00228-012-1284-8

Article (Published version)

Identifiers

PID : unige:31969
DOI : 10.1007/s00228-012-1284-8
PMID : 22546895

Journal ISSN0031-6970

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First validation28/10/2013 16:23:00

Update14/03/2023 20:42:08

Status update14/03/2023 20:42:08

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Intravenous buspirone for the prevention of postoperative nausea and vomiting

Buspirone, a partial 5HT(1A) agonist and D₂ and D₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (PONV) is unknown.

Technical informations