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Scientific article
English

Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection

Published inCardiovascular drugs and therapy, vol. 26, no. 3, p. 227-237
Publication date2012
Abstract

We studied the role of two powerful molecular signalling mechanisms involved in the cardioprotective effect of sphingosine-1-phosphate (S1P), a major component of high density lipoprotein (HDL) against myocardial ischaemic-reperfusion injury, namely the RISK pathway (Akt/Erk), including its downstream target FOXO-1 and, the SAFE pathway (TNF/STAT-3).

Keywords
  • Animals
  • Cardiotonic Agents/pharmacology/therapeutic use
  • Extracellular Signal-Regulated MAP Kinases/metabolism
  • Forkhead Transcription Factors/metabolism
  • Lysophospholipids/pharmacology/therapeutic use
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Infarction/drug therapy/metabolism/pathology
  • Myocardial Reperfusion Injury/drug therapy/metabolism/pathology
  • Proto-Oncogene Proteins c-akt/metabolism
  • STAT3 Transcription Factor/genetics/metabolism
  • Signal Transduction/drug effects
  • Sphingosine/analogs & derivatives/pharmacology/therapeutic use
  • Tumor Necrosis Factor-alpha/genetics/metabolism
Citation (ISO format)
SOMERS, Sarin J et al. Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. In: Cardiovascular drugs and therapy, 2012, vol. 26, n° 3, p. 227–237. doi: 10.1007/s10557-012-6376-2
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0920-3206
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