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Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection

Somers, Sarin J
Lacerda, Lydia
Opie, Lionel H
Lecour, Sandrine
Published in Cardiovascular Drugs and Therapy. 2012, vol. 26, no. 3, p. 227-37
Abstract We studied the role of two powerful molecular signalling mechanisms involved in the cardioprotective effect of sphingosine-1-phosphate (S1P), a major component of high density lipoprotein (HDL) against myocardial ischaemic-reperfusion injury, namely the RISK pathway (Akt/Erk), including its downstream target FOXO-1 and, the SAFE pathway (TNF/STAT-3).
Keywords AnimalsCardiotonic Agents/pharmacology/therapeutic useExtracellular Signal-Regulated MAP Kinases/metabolismForkhead Transcription Factors/metabolismLysophospholipids/pharmacology/therapeutic useMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial Infarction/drug therapy/metabolism/pathologyMyocardial Reperfusion Injury/drug therapy/metabolism/pathologyProto-Oncogene Proteins c-akt/metabolismSTAT3 Transcription Factor/genetics/metabolismSignal Transduction/drug effectsSphingosine/analogs & derivatives/pharmacology/therapeutic useTumor Necrosis Factor-alpha/genetics/metabolism
PMID: 22392184
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Research group Lipoprotéines sériques (598)
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SOMERS, Sarin J et al. Interplay between SAFE and RISK pathways in sphingosine-1-phosphate-induced cardioprotection. In: Cardiovascular Drugs and Therapy, 2012, vol. 26, n° 3, p. 227-37. doi: 10.1007/s10557-012-6376-2 https://archive-ouverte.unige.ch/unige:31964

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Deposited on : 2013-12-10

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