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Scientific article
English

Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women

Published inAntiviral therapy, vol. 18, no. 2, p. 171-182
Publication date2013
Abstract

Physiological changes associated with pregnancy may alter antiretroviral plasma concentrations and might jeopardize prevention of mother-to-child HIV transmission. Lopinavir is one of the protease inhibitors more frequently prescribed during pregnancy in Europe. We described the free and total pharmacokinetics of lopinavir in HIV-infected pregnant and non-pregnant women, and evaluated whether significant alterations in its disposition and protein binding warrant systematic dosage adjustment.

Keywords
  • Adult
  • Anti-HIV Agents/administration & dosage/pharmacokinetics
  • Blood Proteins/metabolism
  • Delivery, Obstetric
  • Female
  • HIV Infections/blood/drug therapy/transmission
  • Humans
  • Lopinavir/administration & dosage/pharmacokinetics
  • Maternal-Fetal Exchange
  • Middle Aged
  • Orosomucoid/metabolism
  • Postpartum Period/blood
  • Pregnancy
  • Prospective Studies
  • Protein Binding
  • Serum Albumin/metabolism
  • Young Adult
Citation (ISO format)
FAYET-MELLO, Aurélie et al. Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women. In: Antiviral therapy, 2013, vol. 18, n° 2, p. 171–182. doi: 10.3851/IMP2328
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Article (Published version)
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Identifiers
ISSN of the journal1359-6535
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