Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women

Fayet-Mello, Aurélie; Buclin, Thierry; Guignard, Nicole; Cruchon, Sandra; Cavassini, Matthias; Grawe, Claudia; Gremlich, Erika; Popp, Karoline Aebi; Schmid, Flavia; Eap, Chin Bin; Telenti, Amalio; Biollaz, Jérôme; Decosterd, Laurent; Martinez De Tejada Weber, Begona

doi:10.3851/IMP2328

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Title		Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women
Authors		Fayet-Mello, Aurélie Buclin, Thierry Guignard, Nicole Cruchon, Sandra Cavassini, Matthias Grawe, Claudia Gremlich, Erika Popp, Karoline Aebi Schmid, Flavia Eap, Chin Bin Telenti, Amalio Biollaz, Jérôme Decosterd, Laurent Martinez De Tejada Weber, Begona show all authors [1 - 14]
Published in		Antiviral therapy. 2013, vol. 18, no. 2, p. 171-82
Abstract		Physiological changes associated with pregnancy may alter antiretroviral plasma concentrations and might jeopardize prevention of mother-to-child HIV transmission. Lopinavir is one of the protease inhibitors more frequently prescribed during pregnancy in Europe. We described the free and total pharmacokinetics of lopinavir in HIV-infected pregnant and non-pregnant women, and evaluated whether significant alterations in its disposition and protein binding warrant systematic dosage adjustment.
Keywords		Adult — Anti-HIV Agents/administration & dosage/pharmacokinetics — Blood Proteins/metabolism — Delivery, Obstetric — Female — HIV Infections/blood/drug therapy/transmission — Humans — Lopinavir/administration & dosage/pharmacokinetics — Maternal-Fetal Exchange — Middle Aged — Orosomucoid/metabolism — Postpartum Period/blood — Pregnancy — Prospective Studies — Protein Binding — Serum Albumin/metabolism — Young Adult
Identifiers		DOI: 10.3851/IMP2328 PMID: 22914504
Full text		Article (Published version) (586 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group		Martinez De Tejada Begona (272)
Citation (ISO format)		FAYET-MELLO, Aurélie et al. Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women. In: Antiviral therapy, 2013, vol. 18, n° 2, p. 171-82. doi: 10.3851/IMP2328 https://archive-ouverte.unige.ch/unige:31943