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Title

Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women

Authors
Fayet-Mello, Aurélie
Guignard, Nicole
Cruchon, Sandra
Cavassini, Matthias
Grawe, Claudia
Gremlich, Erika
Popp, Karoline Aebi
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Published in Antiviral Therapy. 2013, vol. 18, no. 2, p. 171-82
Abstract Physiological changes associated with pregnancy may alter antiretroviral plasma concentrations and might jeopardize prevention of mother-to-child HIV transmission. Lopinavir is one of the protease inhibitors more frequently prescribed during pregnancy in Europe. We described the free and total pharmacokinetics of lopinavir in HIV-infected pregnant and non-pregnant women, and evaluated whether significant alterations in its disposition and protein binding warrant systematic dosage adjustment.
Keywords AdultAnti-HIV Agents/administration & dosage/pharmacokineticsBlood Proteins/metabolismDelivery, ObstetricFemaleHIV Infections/blood/drug therapy/transmissionHumansLopinavir/administration & dosage/pharmacokineticsMaternal-Fetal ExchangeMiddle AgedOrosomucoid/metabolismPostpartum Period/bloodPregnancyProspective StudiesProtein BindingSerum Albumin/metabolismYoung Adult
Identifiers
PMID: 22914504
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Research group Groupe Irion Olivier/Boulvain Michel (gynécologie et obstétrique) (272)
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FAYET-MELLO, Aurélie et al. Free and total plasma levels of lopinavir during pregnancy, at delivery and postpartum: implications for dosage adjustments in pregnant women. In: Antiviral Therapy, 2013, vol. 18, n° 2, p. 171-82. https://archive-ouverte.unige.ch/unige:31943

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Deposited on : 2013-12-10

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