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Influence of CRTC1, CRTC2 and HSD11B1 genetic polymorphisms on gene expression in fibroblasts

ContributorsGuay, Sabrina
DirectorsEap, Chin Bin
Master program titleMaster en Pharmacie - Travail personel de recherche
Defense date2013
Abstract

Obesity has taken an epidemic proportion since the 1980s all around the world. It leads to metabolic complications and reduces lifespan. The psychiatric population, in particular those treated with certain psychotropic drugs, has been shown to have higher rates of obesity than the general population. CREB-regulated transcription coactivator 1 (CRTC1), CREB-regulated transcription coactivator 2 (CRTC2) and 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1) polymorphisms have shown significant association with obesity and type 2 diabetes in psychiatric patients receiving psychotropics (previous studies done at the UPPC). Exploring pharmacogenetics, regarding influence of polymorphisms on gene expression, may lead to a better understanding of obesity pathogenesis.However, influence of CRTC1, CRTC2 and HSD11B1 polymorphisms on gene expression is unknown.

eng
Citation (ISO format)
GUAY, Sabrina. Influence of CRTC1, CRTC2 and HSD11B1 genetic polymorphisms on gene expression in fibroblasts. 2013.
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Master thesis
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  • PID : unige:31933
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Creation12/09/2013 9:59:00 AM
First validation12/09/2013 9:59:00 AM
Update time03/14/2023 8:41:55 PM
Status update03/14/2023 8:41:55 PM
Last indexation01/29/2024 8:01:01 PM
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