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Title

Successful serology-based intervention to increase protection against vaccine-preventable diseases in liver-transplanted children: a 19-yr review of the Swiss national reference center

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Published in Pediatric Transplantation. 2012, vol. 16, no. 1, p. 50-7
Abstract As children referred for OLT in Switzerland were not vaccinated optimally, new guidelines were developed and recommended to base catch-up immunization on serum antibody titers against vaccine-preventable diseases, before and after OLT. We measure the results of this serology-based intervention by comparing vaccine coverage and antibody titers in the pre- (1990-2002, P1) and post-intervention (2003-2008, P2) cohorts in a quality control project. Forty-four P1 and 30 P2 children were evaluated. At pre-OLT visit, D, T, SPn, and MMR serologies were checked more frequently in P2 than P1 (p < 0.05). More P2 children were up-to-date for DTaP and MMR (p < 0.05) or had received ≥1 dose of HBV, HAV, SPn, and VZV vaccines (p < 0.05). One yr post-OLT, DT, SPn, MMR, and VZV serologies were more frequently checked (p < 0.05), and antibody titers were higher for DT and HAV (p < 0.05) in P2. Gender, age, or diagnosis did not explain these differences. Among P2 patients, pre- and post-OLT titers for D, T, Hib, HBV, SPn14, and SPn19 were correlated (p < 0.05 for all). Protection against vaccine-preventable diseases of high-risk children like OLT patients can be significantly improved by serology-based intervention for vaccine-preventable diseases.
Keywords ChildChild, PreschoolCohort StudiesCommunicable Disease ControlFemaleHumansImmunization ScheduleInfantLiver Failure/blood/complications/virologyLiver Transplantation/methodsMaleQuality ControlRegistriesSerology/methodsSwitzerlandTreatment OutcomeVaccination/methodsVaccines/therapeutic useVirus Diseases/complications/prevention & control
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PMID: 22093802
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Structures
Research groups Centre de Vaccinologie et d'Immunologie néonatale (177)
Gastroentérologie et transplantation (pédiatrie) (181)
Recherche en infectiologie pédiatrique et en pédiatrie générale (853)
Recherche clinique en chirurgie pédiatrique (886)
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(ISO format)
L'HUILLIER, Arnaud et al. Successful serology-based intervention to increase protection against vaccine-preventable diseases in liver-transplanted children: a 19-yr review of the Swiss national reference center. In: Pediatric Transplantation, 2012, vol. 16, n° 1, p. 50-7. doi: 10.1111/j.1399-3046.2011.01600.x https://archive-ouverte.unige.ch/unige:31712

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Deposited on : 2013-12-04

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