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Prévention de l'hyperalgésie en postopératoire

Published in Annales françaises d'anesthésie et de réanimation. 2012, vol. 31, no. 1, p. e39-42
Abstract Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia. Different drugs, most of which are NMDA receptors antagonists, are used to decrease or prevent the risk of central or opiate-induced hyperalgesia. However, it is difficult to determine whether they are really effective and at which dosage: the results of most published studies are difficult to interpret because of methodological problems. The two most frequent of those are: absence of objective measurement of secondary hyperalgesia and difficulties targeting an at risk population.
Keywords Amantadine/therapeutic useAmines/therapeutic useAnalgesics, Non-Narcotic/therapeutic useAnalgesics, Opioid/adverse effects/therapeutic useCyclohexanecarboxylic Acids/therapeutic useExcitatory Amino Acid Antagonists/therapeutic useHumansHyperalgesia/chemically induced/etiology/prevention & controlKetamine/therapeutic useMagnesium Compounds/therapeutic usePain Management/methodsPain, Postoperative/chemically induced/prevention & controlReceptors, N-Methyl-D-Aspartate/antagonists & inhibitorsRisk AssessmentGamma-Aminobutyric Acid/therapeutic use
PMID: 22177778
Note Congrès de l'Adarpef - Texte présenté au 31e Congrès national de l’association des anesthésistes réanimateurs pédiatriques d’expression française, 1er – 2 avril 2011 à Reims.
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Research group Enfants et hyperréactivité bronchique (69)
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MAMIE, Chantal. Prévention de l'hyperalgésie en postopératoire. In: Annales françaises d'anesthésie et de réanimation, 2012, vol. 31, n° 1, p. e39-42. https://archive-ouverte.unige.ch/unige:31694

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Deposited on : 2013-12-04

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